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Trends in Incidence and Prevalence of Major Transfusion-Transmissible Viral Infections in US Blood Donors, 1991 to 1996
Simone A. Glynn, MD, MSc, MPH;
Steven H. Kleinman, MD;
George B Schreiber, ScD;
Michael P. Busch, MD, PhD;
David J. Wright, PhD;
James W. Smith, MD;
Catharie C. Nass, PhD;
Alan E. Williams, PhD;
for the Retrovirus Epidemiology Donor Study (REDS)
JAMA. 2000;284:229-235.
Context Evaluating trends in blood donor infectious disease rates is essential for monitoring blood supply safety and donor screening effectiveness.
Objective To determine changes over time in blood donor population infection rates of human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis C virus (HCV), and hepatitis B virus (HBV).
Design Cross-sectional survey data from the National Heart, Lung, and Blood Institute–sponsored Retrovirus Epidemiology Donor Study.
Setting Five blood centers in different regions of the United States.
Participants A total of 1.9 million volunteer blood donors with 1 or more nonautologous donations from January 1991 to December 1996.
Main Outcome Measures Changes in rates of HIV, HTLV, HCV, and HBV infections were evaluated by comparing yearly prevalence estimates (per 100,000 donations) for first-time allogeneic donors and period-specific incidence rates (IRs) (per 100,000 person-years) for repeat allogeneic donors between 1991 and 1996 (for HCV, from about March 1992 to June 1996).
Results Prevalence of HIV decreased in first-time donors from 0.030% to 0.015% (P=.006) and HCV prevalence decreased from 0.63% to 0.40% (P<.001). Trends were not statistically significant for the proportion of first-time donors with hepatitis B surface antigen (HBsAg) or HTLV. For repeat donors, IRs did not change significantly, indicating a stable but low level of seroconversion. The overall IRs (95% confidence intervals) per 100,000 person-years were 2.92 (2.26-3.70) for HIV, 1.59 (1.12-2.19) for HTLV, 3.25 (2.36-4.36) for HCV, and an estimated 10.43 (7.99-13.37) for HBV (based on an HBsAg rate of 2.66 [2.04-3.41] with presumed false-positive results considered negative). The HBV IR estimate with presumed false-positive results considered positive (for comparability to previous analyses) was 17.83 (14.60-21.56).
Conclusion The decrease in HIV and HCV prevalence rates, combined with the previously documented lower rates of infection in first-time donors compared with the general population, suggests the continued benefit of behavioral risk factor screening.
Author Affiliations: Westat, Rockville, Md (Drs Glynn, Kleinman, Schreiber, and Wright); Blood Centers of the Pacific and the University of California, San Francisco, and Blood Systems Inc, Scottsdale, Ariz (Dr Busch); The Oklahoma Blood Institute, Oklahoma City (Dr Smith); American Red Cross Blood Services-Greater Chesapeake and Potomac Region, Baltimore, Md (Dr Nass); and Holland Laboratory, American Red Cross Biomedical Services, Rockville, Md (Dr Williams).
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