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  Vol. 284 No. 21, December 6, 2000 TABLE OF CONTENTS
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Individual Cholesterol Variation in Response to a Margarine- or Butter-Based Diet

A Study in Families

Margo A. Denke, MD; Beverley Adams-Huet, MS; Anh T. Nguyen, BS

JAMA. 2000;284:2740-2747.

Context  The effectiveness of dietary modification in reducing low-density lipoprotein cholesterol (LDL-C) levels can be reliably predicted for populations, but not for individuals.

Objective  To determine whether individual variation in cholesterol response to dietary modification is a familial trait.

Design  Two-period, outpatient crossover trial conducted from September 1997 to September 1999.

Setting and Participants  Fifty-six families from the Dallas–Ft Worth, Tex, area with 2 biological parents and at least 2 children aged 5 years or older volunteered; 46 families (n = 92 adults and n = 134 children) completed the study.

Intervention  All families followed two 5-week dietary regimens that included individualized daily dietary prescriptions and emphasized a low–saturated fat diet supplemented with specially manufactured baked goods and spreadable fat. One regimen used butter only and the other used margarine only.

Main Outcome Measure  Mean LDL-C levels during the last 2 weeks of each dietary period.

Results  Margarine intake compared with butter intake lowered LDL-C levels 11% in adults (95% confidence interval [CI], 13% to 9%) and 9% in children (95% CI, 12% to 6%) (P<.001 for both adults and children). The distribution of individual responses were peaked around the mean response. For adults and children together, family membership accounted for 19% of variability in response (P = .007). In children, family membership accounted for 40% of variability in response of percent change in LDL-C levels (P = .002). Body mass index and change in cholesterol ester (CE) 18:2/18:1 ratio accounted for 26% of variation, leaving 26% still attributable to family membership. In all participants, BMI predicted response—heavier individuals had higher LDL-C levels, less excursion in CE fatty acids, and less LDL-C response to dietary change.

Conclusions  Our results suggest that individual variation in response to a cholesterol-lowering diet is a familial trait. Body weight is an important modifiable factor that influences response.


Author Affiliations: Department of Internal Medicine (Dr Denke and Ms Adams-Huet) and Center for Human Nutrition (Dr Denke and Ms Nguyen), University of Texas Southwestern Medical Center, Dallas.


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