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Mark H. Ebell, MD; Mindy A. Smith, MD; Henry C. Barry, MD; Kathy Ives, BS; Mark Carey, BS

JAMA. 2000;284:2912-2918.

Context  Sore throat is a common complaint, and identifying patients with group A -hemolytic streptococcal pharyngitis (strep throat) is an important task for clinicians. Previous reviews have not systematically reviewed and synthesized the evidence.

Objective  To review the precision and accuracy of the clinical examination in diagnosing strep throat.

Data Source  MEDLINE search for articles about diagnosis of strep throat using history-taking and physical examination.

Study Selection  Large blinded, prospective studies (having 300 patients with sore throat) reporting history and physical examination data and using throat culture as the reference standard were included. Of 917 articles identified by the search, 9 met all inclusion criteria.

Data Extraction  Pairs of authors independently reviewed each article and used consensus to resolve discrepancies.

Data Synthesis  The most useful findings for evaluating the likelihood of strep throat are presence of tonsillar exudate, pharyngeal exudate, or exposure to strep throat infection in the previous 2 weeks (positive likelihood ratios, 3.4, 2.1, and 1.9, respectively) and the absence of tender anterior cervical nodes, tonsillar enlargement, or exudate (negative likelihood ratios, 0.60, 0.63, and 0.74, respectively). No individual element of history-taking or physical examination is accurate enough by itself to rule in or rule out strep throat. Three validated clinical prediction rules are described for adult and pediatric populations.

Conclusions  While no single element of history-taking or physical examination is sufficiently accurate to exclude or diagnose strep throat, a well-validated clinical prediction rule can be useful and can help physicians make more informed use of rapid antigen tests and throat cultures.

Author Affiliations: Michigan State University, East Lansing (Drs Ebell, Smith, and Barry, Ms Ives; and Mr Carey); First Consulting Group, Okemos, Mich (Ms Ives).

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