You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT JAMA
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 285 No. 5, February 7, 2001 TABLE OF CONTENTS
  JAMA
  •  Online Features
  Opportunities for Medical Research
 This Article
 •Full text
 •PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on Web of Science (195)
 •Contact me when this article is cited
 Related Content
 •Related letter
 •Related article
 •Similar articles in JAMA
 Topic Collections
 •World Health
 •Statistics and Research Methods
 •Alert me on articles by topic
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Burden of Disease—Implications for Future Research

Catherine M. Michaud, MD, PhD; Christopher J. L. Murray, MD, DPhil; Barry R. Bloom, PhD

JAMA. 2001;285:535-539.

One overall challenge for public health and medicine in the future is to allocate available resources effectively to reduce major causes of disease burden globally and to decrease health disparities between poor and affluent populations. The major risk factors for death and disability worldwide are malnutrition; poor water supply, sanitation, and personal and domestic hygiene; unsafe sexual behavior; tobacco use; alcohol use; occupational hazards; hypertension; physical inactivity; illicit drugs; and air pollution. The challenge for research in the 21st century is to maintain and improve life expectancy and the quality of life that was achieved for most of the world's population during the 20th century.


Author Affiliations: Department of Population and International Health, Harvard School of Public Health, Boston, Mass.



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

RELATED LETTER

Medical Research in the 21st Century
Adolph H. Giesecke, Charles Gessert, John W. Beasley, Edward Shahady, Catherine Michaud, David G. Nathan, Phil B. Fontanarosa, and Jean D. Wilson
JAMA. 2001;286(15):1833-1835.
EXTRACT | FULL TEXT  

RELATED ARTICLE

February 7, 2001
JAMA. 2001;285(5):665-666.
EXTRACT | FULL TEXT  


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The statewide burden of obesity, smoking, low income and chronic diseases in the United States
Jia and Lubetkin
J Public Health (Oxf) 2009;0:fdp012v1-10.
ABSTRACT | FULL TEXT  

Prognostic utility of 64-slice computed tomography in patients with suspected but no documented coronary artery disease
Carrigan et al.
Eur Heart J 2009;30:362-371.
ABSTRACT | FULL TEXT  

The Physician as Public Health Professional in the 21st Century
Shortell and Swartzberg
JAMA 2008;300:2916-2918.
FULL TEXT  

Obesity and respiratory diseases
Murugan and Sharma
Chronic Respiratory Disease 2008;5:233-242.
ABSTRACT  

Single histidine-substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction
Palpant et al.
Cardiovasc Res 2008;80:209-218.
ABSTRACT | FULL TEXT  

Prostacyclin Prevents Murine Lung Cancer Independent of the Membrane Receptor by Activation of Peroxisomal Proliferator-Activated Receptor {gamma}
Nemenoff et al.
Cancer Prevention Research 2008;1:349-356.
ABSTRACT | FULL TEXT  

Palliative and end-of-life care for patients with severe COPD
Curtis
Eur Respir J 2008;32:796-803.
ABSTRACT | FULL TEXT  

Oxygen-enhanced Magnetic Resonance Imaging versus Computed Tomography: Multicenter Study for Clinical Stage Classification of Smoking-related Chronic Obstructive Pulmonary Disease
Ohno et al.
Am. J. Respir. Crit. Care Med. 2008;177:1095-1102.
ABSTRACT | FULL TEXT  

Another Step Forward in CT Angiography.
Lima
J Am Coll Cardiol Img 2008;1:187-189.
FULL TEXT  

Problem-Solving Therapy for Depression in Adults: A Systematic Review
Gellis and Kenaley
Research on Social Work Practice 2008;18:117-131.
ABSTRACT  

Dynamic Oxygen-Enhanced MRI Versus Quantitative CT: Pulmonary Functional Loss Assessment and Clinical Stage Classification of Smoking-Related COPD
Ohno et al.
Am. J. Roentgenol. 2008;190:W93-W99.
ABSTRACT | FULL TEXT  

Identifying Research Priorities: The Value of Information Associated with Repeat Screening for Age-Related Macular Degeneration
Bojke et al.
Med Decis Making 2008;28:33-43.
ABSTRACT  

Electroconvulsive Therapy for Depression
Lisanby
NEJM 2007;357:1939-1945.
FULL TEXT  

Depressive Disorders Related to Female Reproductive Transitions
Serrano and Warnock
Journal of Pharmacy Practice 2007;20:385-391.
ABSTRACT  

The Epidemiology and Economics of Chronic Obstructive Pulmonary Disease
Mannino and Braman
Proc Am Thorac Soc 2007;4:502-506.
ABSTRACT | FULL TEXT  

A Systematic Review of the Prothrombotic Effects of an Acute Change in Posture: A Possible Mechanism Underlying the Morning Excess in Cardiovascular Events?
Thrall et al.
Chest 2007;132:1337-1347.
ABSTRACT | FULL TEXT  

JAMA's Contributing Writers
DeAngelis and Fontanarosa
JAMA 2007;297:2139-2140.
FULL TEXT  

Optimal Treatment of Chronic Obstructive Pulmonary Disease: The Search for the Magic Combination of Inhaled Bronchodilators and Corticosteroids
Criner
ANN INTERN MED 2007;146:606-608.
FULL TEXT  

Vagus Nerve Stimulation Therapy for Treatment of Drug-Resistant Epilepsy and Depression
Shafique and Dalsing
PERSPECT VASC SURG ENDOVASC THER 2006;18:323-327.
ABSTRACT  

Donor funding priorities for communicable disease control in the developing world
Shiffman
Health Policy Plan 2006;21:411-420.
ABSTRACT | FULL TEXT  

Cigarette Smoking Saturates Brain {alpha}4beta2 Nicotinic Acetylcholine Receptors.
Brody et al.
Arch Gen Psychiatry 2006;63:907-914.
ABSTRACT | FULL TEXT  

The natural history of chronic obstructive pulmonary disease.
Mannino et al.
Eur Respir J 2006;27:627-643.
FULL TEXT  

Longitudinal Trends in Race/Ethnic Disparities in Leading Health Indicators From Adolescence to Young Adulthood
Harris et al.
Arch Pediatr Adolesc Med 2006;160:74-81.
ABSTRACT | FULL TEXT  

Lung NF-{kappa}B Activation and Neutrophil Recruitment Require IL-1 and TNF Receptor Signaling during Pneumococcal Pneumonia
Jones et al.
J. Immunol. 2005;175:7530-7535.
ABSTRACT | FULL TEXT  

HIV/AIDS prevention in Uganda: why has it worked?
Genuis and Genuis
Postgrad. Med. J. 2005;81:615-617.
FULL TEXT  

Biofeedback-Assisted Relaxation in Type 2 Diabetes
McGinnis et al.
Diabetes Care 2005;28:2145-2149.
ABSTRACT | FULL TEXT  

Live Attenuated Influenza Vaccine, Trivalent, Is Safe in Healthy Children 18 Months to 4 Years, 5 to 9 Years, and 10 to 18 Years of Age in a Community-Based, Nonrandomized, Open-Label Trial
Piedra et al.
Pediatrics 2005;116:e397-e407.
ABSTRACT | FULL TEXT  

Identifying and pursuing research priorities at the National Center for Complementary and Alternative Medicine
Nahin
FASEB J. 2005;19:1209-1215.
ABSTRACT | FULL TEXT  

Can We Better Prioritize Resources for Cost-Utility Research?
Neumann et al.
Med Decis Making 2005;25:429-436.
ABSTRACT  

Depression and All-Cause and Coronary Heart Disease Mortality Among Adults With and Without Diabetes
Egede et al.
Diabetes Care 2005;28:1339-1345.
ABSTRACT | FULL TEXT  

Systemic Response to Ambient Particulate Matter: Relevance to Chronic Obstructive Pulmonary Disease
van Eeden et al.
Proc Am Thorac Soc 2005;2:61-67.
ABSTRACT | FULL TEXT  

Sexual behaviour: related adverse health burden in the United States
Ebrahim et al.
Sex. Transm. Infect. 2005;81:38-40.
ABSTRACT | FULL TEXT  

Hospice use for the patient with advanced Alzheimer's disease: The role of the geriatric psychiatrist
Aupperle et al.
AM J HOSP PALLIAT CARE 2004;21:427-437.
ABSTRACT  

Statin-Induced Cholesterol Lowering and Plaque Regression After 6 Months of Magnetic Resonance Imaging-Monitored Therapy
Lima et al.
Circulation 2004;110:2336-2341.
ABSTRACT | FULL TEXT  

Treatment Outcome and Physician-Patient Communication in Primary Care Patients With Chronic, Recurrent Depression
Schwenk et al.
Am. J. Psychiatry 2004;161:1892-1901.
ABSTRACT | FULL TEXT  

Pulmonary Prostacyclin Synthase Overexpression Chemoprevents Tobacco Smoke Lung Carcinogenesis in Mice
Keith et al.
Cancer Res. 2004;64:5897-5904.
ABSTRACT | FULL TEXT  

Relation between randomized controlled trials published in leading general medical journals and the global burden of disease
Rochon et al.
CMAJ 2004;170:1673-1677.
ABSTRACT | FULL TEXT  

Actual Causes of Death in the United States, 2000
Mokdad et al.
JAMA 2004;291:1238-1245.
ABSTRACT | FULL TEXT  

Hospice use for the patient with advanced Alzheimer's disease: The role of the geriatric psychiatrist
Aupperle et al.
AM J ALZHEIMERS DIS OTHER DEMEN 2004;19:94-104.
ABSTRACT  

Diabetes, Major Depression, and Functional Disability Among U.S. Adults
Egede
Diabetes Care 2004;27:421-428.
ABSTRACT | FULL TEXT  

Implications of Regional Differences in Spending
Fernandes
ANN INTERN MED 2004;140:146-147.
FULL TEXT  

Direct and Total Effectiveness of the Intranasal, Live-Attenuated, Trivalent Cold-Adapted Influenza Virus Vaccine Against the 2000-2001 Influenza A(H1N1) and B Epidemic in Healthy Children
Gaglani et al.
Arch Pediatr Adolesc Med 2004;158:65-73.
ABSTRACT | FULL TEXT  

Contemporary Management of Chronic Obstructive Pulmonary Disease: Scientific Review
Sin et al.
JAMA 2003;290:2301-2312.
ABSTRACT | FULL TEXT  

Nuclear Factor-{kappa}B p50 Limits Inflammation and Prevents Lung Injury during Escherichia coli Pneumonia
Mizgerd et al.
Am. J. Respir. Crit. Care Med. 2003;168:810-817.
ABSTRACT | FULL TEXT  

Global Health--Targeting Problems and Achieving Solutions: A Call for Papers
Flanagin and Winker
JAMA 2003;290:1382-1384.
FULL TEXT  

Poststroke patients: implications for the cardiologist
Fox
Eur Heart J Suppl 2003;5:E4-E10.
ABSTRACT  

Inhaled corticosteroids and survival in chronic obstructive pulmonary disease: does the dose matter?
Sin and Man
Eur Respir J 2003;21:260-266.
ABSTRACT | FULL TEXT  

Functions of I{kappa}B Proteins in Inflammatory Responses to Escherichia coli LPS in Mouse Lungs
Mizgerd et al.
Am. J. Respir. Cell Mol. Bio. 2002;27:575-582.
ABSTRACT | FULL TEXT  

World Heart Day 2002: The International Burden of Cardiovascular Disease: Responding to the Emerging Global Epidemic
Bonow et al.
Circulation 2002;106:1602-1605.
FULL TEXT  

Task Force #5--the role of cardiovascular specialists as leaders in prevention: from training to champion
Merz et al.
J Am Coll Cardiol 2002;40:641-649.
FULL TEXT  

Toward Wisdom From Failure: Lessons From Neuroprotective Stroke Trials and New Therapeutic Directions
Gladstone et al.
Stroke 2002;33:2123-2136.
ABSTRACT | FULL TEXT  

The Most Expensive Medical Conditions In America
Druss et al.
Health Aff (Millwood) 2002;21:105-111.
ABSTRACT | FULL TEXT  

COPD* : Epidemiology, Prevalence, Morbidity and Mortality, and Disease Heterogeneity
Mannino
Chest 2002;121 :121S-126S.
ABSTRACT | FULL TEXT  

The Unending String
Murray
Arch Pediatr Adolesc Med 2001;155:1193-1194.
FULL TEXT  

Medical Research in the 21st Century
Giesecke et al.
JAMA 2001;286:1833-1835.
FULL TEXT  

One Hundred Years of Chronic Obstructive Pulmonary Disease
Fishman
Am. J. Respir. Crit. Care Med. 2005;171:941-948.
FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 2001 American Medical Association. All Rights Reserved.