This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (15)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Topic Collections  • Statistics and Research Methods  • Genetics  • Genetic Counseling/ Testing/ Therapy  • Genetics, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Thomas F. Bumol, PhD; August M. Watanabe, MD

JAMA. 2001;285:551-555.

The completion of the first draft of the human genome has provided an unprecedented opportunity to understand the genetic and molecular basis of disease. Parallel developments of new biological technologies, such as transcript profiling, allow scientists to examine almost any biological system in high molecular resolution. Contemporary drug discovery research is now focusing on the identification and validation of pharmaceutical targets in the molecular pathways/systems embedded in this information. Novel therapeutic interventions are being developed and evaluated as a result of this research which will be the basis of innovative pharmaceuticals of the future.

Author Affiliation: Research Technologies and Proteins, Lilly Research Laboratories, Indianapolis, Ind.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The long road of biopharmaceutical drug development: from inception to marketing
Mundae and Ostor
QJM 2009;0:hcp145v1-hcp145.
ABSTRACT | FULL TEXT  

Primer on Medical Genomics Part III: Microarray Experiments and Data Analysis
Tefferi et al.
Mayo Clin Proc. 2002;77:927-940.
ABSTRACT  

The promise of human genetic databases
Lowrance
BMJ 2001;322:1009-1010.
FULL TEXT