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Robert J. Lefkowitz, MD; James T. Willerson, MD

JAMA. 2001;285:581-587.

Cardiovascular disease is the greatest threat to human life and health. The past decade has seen remarkable progress in clinical and basic cardiovascular research, and many areas of opportunity are promising. The pace of current progress in clinical and basic research is such that remarkable improvement in the quality and length of life for those at risk for cardiovascular disease is likely.

Author Affiliations: Howard Hughes Medical Institute, Chevy Chase, Md, and Departments of Medicine and Biochemistry, Duke University, Durham, NC (Dr Lefkowitz); Texas Heart Institute, Houston, and Department of Internal Medicine, University of Texas Medical School, Houston (Dr Willerson).

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