Toward Mechanism-Based Cancer Care
David M. Livingston, MD;
Ramesh Shivdasani, MD
JAMA. 2001;285:588-593.
In the past 25 years, research has elucidated molecular mechanisms directing key aspects of tumor cell behavior. Detailed understanding of these mechanisms has already changed methods for diagnosis, prognosis, and treatment. With continuing advances in cancer science and the emergence of new technologies for applying basic science to clinical practice, new methods based on molecular mechanisms will dominate cancer care and prevention.
Author Affiliations: Dana-Farber Cancer Institute and Harvard Medical School, Boston, Mass.
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