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Prospects for Vaccines to Protect Against AIDS, Tuberculosis, and Malaria
Norman L. Letvin, MD;
Barry R. Bloom, PhD;
Stephen L. Hoffman, MD
JAMA. 2001;285:606-611.
Given the scope of the worldwide health problems caused by the acquired immunodeficiency syndrome, tuberculosis, and malaria, it is imperative that vaccines be developed to prevent these infections. Recent advances in the understanding of these diseases suggest that T-lymphocyte–mediated immunity is important in containing these infections. The application of novel vaccine technologies for eliciting this type of immunity promises to provide successful vaccines for controlling the spread of these deadly infections.
Author Affiliations: Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Mass (Dr Letvin); Office of the Dean, Harvard School of Public Health, Boston, Mass (Dr Bloom); and Malaria Department, Naval Medical Research Center, Silver Spring, Md (Dr Hoffman).
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