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Jerrold M. Olefsky, MD

JAMA. 2001;285:628-632.

Diabetes mellitus is the sixth leading cause of death in the United States, and morbidities resulting from diabetes-related complications such as retinopathy, kidney disease, and limb amputation cause a huge burden to the national health care system. Identification of the genetic components of type 1 and type 2 diabetes is the most important area of research because elucidation of the diabetes genes will influence all efforts toward a mechanistic understanding of the disease, its complications, and its treatment, cure, and prevention. Also, the link between obesity and type 2 diabetes mandates a redoubled effort to understand the genetic and behavioral contributions to obesity.

Author Affiliation: Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, and Department of Veterans Affairs, San Diego.

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