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Robert P. Kimberly, MD

JAMA. 2001;285:650-652.

Systemic lupus erythematosus is an autoimmune disease with a significant genetic component to susceptibility. Some environmental risks are known, and identification of specific genetic factors promises to define new molecular targets for therapy. Broad immunosuppression will be replaced by early, selective, and individualized intervention. Mortality rates will decline, and insights into therapy may apply to other autoimmune conditions.

Author Affiliation: Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham.

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