This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (115)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Topic Collections  • Neurology  • Alzheimer Disease  • Dementias  • Alert me on articles by topic

Yoruba Residing in Ibadan, Nigeria, and African Americans Residing in Indianapolis, Indiana

Hugh C. Hendrie, MB, ChB; Adesola Ogunniyi, MD; Kathleen S. Hall, PhD; Olusegun Baiyewu, MD; Frederick W. Unverzagt, PhD; Oye Gureje, MD; Sujuan Gao, PhD; Rebecca M. Evans, MD; A. O. Ogunseyinde, MD; A. O. Adeyinka, MD; Beverly Musick, MS; Siu L. Hui, PhD

JAMA. 2001;285:739-747.

Context  Alzheimer disease (AD) represents a major and increasing public health problem. If populations were identified with significantly lower or higher incidence rates of AD, the search for risk factors in the genesis of AD could be greatly enhanced.

Objective  To compare incidence rates of dementia and AD in 2 diverse, elderly community-dwelling populations.

Design  The Indianapolis-Ibadan Dementia Project, a longitudinal, prospective population-based study consisting of a baseline survey (1992-1993) and 2 subsequent follow-up waves after 2 years (1994-1995) and 5 years (1997-1998). Each wave followed a 2-stage design, with an in-home screening interview followed by a full diagnostic workup of a subsample of participants based on screening performance.

Setting and Participants  A total of 2459 community-dwelling Yoruba residents of Ibadan, Nigeria, without dementia, and 2147 community-dwelling African American residents of Indianapolis, Ind, without dementia (all aged 65 years or older). The cohorts were followed up for a mean of 5.1 years and 4.7 years, respectively.

Main Outcome Measures  Incident cases of dementia and AD in each of the 2 populations.

Results  The age-standardized annual incidence rates were significantly lower among Yoruba than among African Americans for dementia (Yoruba, 1.35% [95% confidence interval {CI}, 1.13%-1.56%]; African Americans, 3.24% [95% CI, 2.11%-4.38%]) and for AD (Yoruba, 1.15% [95% CI, 0.96%-1.35%]; African Americans, 2.52% [95% CI, 1.40%-3.64%]).

Conclusion  This is the first report of incidence rate differences for dementia and AD in studies of 2 populations from nonindustrialized and industrialized countries using identical methods and the same group of investigators in both sites. Further explorations of these population differences may identify potentially modifiable environmental or genetic factors to account for site differences in dementia and AD.

Author Affiliations: Departments of Psychiatry (Drs Hendrie, Hall, and Unverzagt), Medicine (Drs Gao and Hui and Ms Musick), and Neurology (Dr Evans), and The Regenstrief Institute (Drs Hendrie and Hui), Indiana University School of Medicine, Indianapolis; and the Departments of Medicine (Drs Ogunniyi, Baiyewu, and Gureje) and Radiology (Drs Ogunseyinde and Adeyinka), University of Ibadan, Ibadan, Nigeria.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Dementia of the Alzheimer Type
Jalbert et al.
Epidemiol Rev 2008;0:mxn008v1-mxn008.
ABSTRACT | FULL TEXT  

Mild Cognitive Dysfunction: An Epidemiological Perspective With an Emphasis on African Americans
Unverzagt et al.
J Geriatr Psychiatry Neurol 2007;20:215-226.
ABSTRACT  

Association of statin use with cognitive decline in elderly African Americans
Szwast et al.
Neurology 2007;69:1873-1880.
ABSTRACT | FULL TEXT  

Long-term Effects of Cognitive Training on Everyday Functional Outcomes in Older Adults
Willis et al.
JAMA 2006;296:2805-2814.
ABSTRACT | FULL TEXT  

Dementia--Epidemiological Considerations, Nomenclature, and a Tacit Consensus Definition
Breitner
J Geriatr Psychiatry Neurol 2006;19:129-136.
ABSTRACT  

Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction
Qin et al.
J. Biol. Chem. 2006;281:21745-21754.
ABSTRACT | FULL TEXT  

Lessons Learned From International Comparative Crosscultural Studies on Dementia.
Hendrie
AJGP 2006;14:480-488.
ABSTRACT | FULL TEXT  

Effects of a 14-Day Healthy Longevity Lifestyle Program on Cognition and Brain Function.
Small et al.
AJGP 2006;14:538-545.
ABSTRACT | FULL TEXT  

Association of apolipoprotein e genotype and Alzheimer disease in african americans.
Murrell et al.
Arch Neurol 2006;63:431-434.
ABSTRACT | FULL TEXT  

Cholesterol, APOE genotype, and Alzheimer disease: An epidemiologic study of Nigerian Yoruba
Hall et al.
Neurology 2006;66:223-227.
ABSTRACT | FULL TEXT  

Children of Alzheimer Patients: An Overview
Jarvik and Blazer
J Geriatr Psychiatry Neurol 2005;18:181-186.
 

Sensitivity and specificity of dementia coding in two Swedish disease registries
Jin et al.
Neurology 2004;63:739-741.
ABSTRACT | FULL TEXT  

Psychiatric research in Nigeria: bridging tradition and modernisation
Ayonrinde et al.
Br. J. Psychiatry 2004;184:536-538.
FULL TEXT  

Meta-Analysis of the Association of the Cathepsin D Ala224Val Gene Polymorphism with the Risk of Alzheimer's Disease: A HuGE Gene-Disease Association Review
Ntais et al.
Am J Epidemiol 2004;159:527-536.
ABSTRACT | FULL TEXT  

Novel presenilin 1 mutation with profound neurofibrillary pathology in an indigenous Southern African family with early-onset Alzheimer's disease
Heckmann et al.
Brain 2004;127:133-142.
ABSTRACT | FULL TEXT  

Normal Genetic Variation, Cognition, and Aging
Greenwood and Parasuraman
Behav Cogn Neurosci Rev 2003;2:278-306.
ABSTRACT  

Gene-Environment Interactions and the Etiology of Common Complex Disease
Cooper
ANN INTERN MED 2003;139:437-440.
ABSTRACT | FULL TEXT  

Gene-Diet Interactions in Brain Aging and Neurodegenerative Disorders
Mattson
ANN INTERN MED 2003;139:441-444.
ABSTRACT | FULL TEXT  

Managing Alzheimer Dementia Tomorrow
Rosenthal and Khotianov
J Am Board Fam Med 2003;16:423-434.
ABSTRACT | FULL TEXT  

Alzheimer Disease in the US Population: Prevalence Estimates Using the 2000 Census
Hebert et al.
Arch Neurol 2003;60:1119-1122.
ABSTRACT | FULL TEXT  

Genetic vulnerability following traumatic brain injury: the role of apolipoprotein E
Nathoo et al.
Mol. Pathol. 2003;56:132-136.
ABSTRACT | FULL TEXT  

Alzheimer's Disease and Parkinson's Disease
Nussbaum and Ellis
NEJM 2003;348:1356-1364.
FULL TEXT  

Evidence for defective retinoid transport and function in late onset Alzheimer's disease
Goodman and Pardee
Proc. Natl. Acad. Sci. USA 2003;100:2901-2905.
ABSTRACT | FULL TEXT  

Will caloric restriction and folate protect against AD and PD?
Mattson
Neurology 2003;60:690-695.
ABSTRACT | FULL TEXT  

Mental health of the ageing immigrant population
Livingston and Sembhi
Adv. Psychiatr. Treat. 2003;9:31-37.
ABSTRACT | FULL TEXT  

Informant Reports of Changes in Personality Predict Dementia in a Population-Based Study of Elderly African Americans and Yoruba
Smith-Gamble et al.
AJGP 2002;10:724-732.
ABSTRACT | FULL TEXT  

Dementia and Alzheimer Disease Incidence: A Prospective Cohort Study
Kukull et al.
Arch Neurol 2002;59:1737-1746.
ABSTRACT | FULL TEXT  

Methodological Aspects of Comparative Research in the Epidemiology of Alzheimer Disease
de Figueiredo
AJGP 2002;10:373-385.
ABSTRACT | FULL TEXT  

Modification of Brain Aging and Neurodegenerative Disorders by Genes, Diet, and Behavior
Mattson et al.
Physiol. Rev. 2002;82:637-672.
ABSTRACT | FULL TEXT  

Alzheimer Disease
Cummings and Cole
JAMA 2002;287:2335-2338.
FULL TEXT  

Alzheimer Disease as a Vascular Disorder: Nosological Evidence
de la Torre
Stroke 2002;33:1152-1162.
ABSTRACT | FULL TEXT  

Risk of Dementia Among White and African American Relatives of Patients With Alzheimer Disease
Green et al.
JAMA 2002;287:329-336.
ABSTRACT | FULL TEXT  

Hippocampal Atrophy Correlates With Clinical Features of Alzheimer Disease in African Americans
Sencakova et al.
Arch Neurol 2001;58:1593-1597.
ABSTRACT | FULL TEXT  

Incidence of Alzheimer's disease in a rural community in India: The Indo-US Study
Chandra et al.
Neurology 2001;57:985-989.
ABSTRACT | FULL TEXT  

Incidence of Dementia and Alzheimer Disease in Nigeria and the United States
Grant et al.
JAMA 2001;285:2448-2449.
FULL TEXT  

Dementia and Alzheimer's Disease: Does Incidence Differ Across the Globe?
JWatch Neurology 2001;2001:2-2.
FULL TEXT  

Intercontinental Epidemiology of Alzheimer Disease: A Global Approach to Bad Gene Hunting
Farrer
JAMA 2001;285:796-798.
FULL TEXT