Activated Protein C for Sepsis
Toussaint and Gerlach
NEJM 2009;361:2646-2652.
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Effects of Antithrombin III in Patients With Disseminated Intravascular Coagulation Diagnosed by Newly Developed Diagnostic Criteria for Critical Illness
Sawamura et al.
CLIN APPL THROMB HEMOST 2009;15:561-566.
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The Reduced Anticoagulant Effect of Fondaparinux at Low Antithrombin Levels
Dempfle et al.
Anesth. Analg. 2009;109:712-716.
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Immunomodulation in the critically ill
Webster and Galley
Br J Anaesth 2009;103:70-81.
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Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant
Mosnier et al.
Blood 2009;113:5970-5978.
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Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality
Niessen et al.
Blood 2009;113:2859-2866.
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Neither fibrin nor plasminogen activator inhibitor-1 deficiency protects lung function in a mouse model of acute lung injury
Allen et al.
Am. J. Physiol. Lung Cell. Mol. Physiol. 2009;296:L277-L285.
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Distinct Functions of Activated Protein C Differentially Attenuate Acute Kidney Injury
Gupta et al.
J. Am. Soc. Nephrol. 2009;20:267-277.
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Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells
Yang et al.
Proc. Natl. Acad. Sci. USA 2009;106:274-279.
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Thrombocytopenia and thrombosis in disseminated intravascular coagulation (DIC)
Kitchens
ASH Education Book 2009;2009:240-246.
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Dissociation of Activated Protein C Functions by Elimination of Protein S Cofactor Enhancement
Harmon et al.
J. Biol. Chem. 2008;283:30531-30539.
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Early Administration of High-Dose Antithrombin in Severe Sepsis: Single Center Results from the KyberSept-Trial
Eid et al.
Anesth. Analg. 2008;107:1633-1638.
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When Is a Negative Phase II Trial Truly Negative?
Rubenfeld and Abraham
Am. J. Respir. Crit. Care Med. 2008;178:554-555.
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Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production
Lorne et al.
Am. J. Physiol. Cell Physiol. 2008;294:C985-C993.
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Inflammation, endothelium, and coagulation in sepsis
Schouten et al.
J. Leukoc. Biol. 2008;83:536-545.
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Sepsis: A Clinical Update
Ventetuolo and Levy
CJASN 2008;3:571-577.
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Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin
Schuepbach et al.
Blood 2008;111:2667-2673.
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Hydrocortisone Therapy for Patients with Septic Shock
Sprung et al.
NEJM 2008;358:111-124.
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Antithrombin III in critically ill patients
Torossian et al.
BMJ 2007;335:1219-1220.
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Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C
Kerschen et al.
JEM 2007;204:2439-2448.
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Gene Expression Profiling Identifies C/EBP{delta} as a Candidate Regulator of Endotoxin-induced Disseminated Intravascular Coagulation
Slofstra et al.
Am. J. Respir. Crit. Care Med. 2007;176:602-609.
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Natural anticoagulants limit lipopolysaccharide-induced pulmonary coagulation but not inflammation
Choi et al.
Eur Respir J 2007;30:423-428.
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Antithrombin Levels, Morbidity, and Mortality in a Surgical Intensive Care Unit
Sakr et al.
Anesth. Analg. 2007;105:715-723.
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The cytoprotective protein C pathway
Mosnier et al.
Blood 2007;109:3161-3172.
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A Prospective Comparison of New Japanese Criteria for Disseminated Intravascular Coagulation: New Japanese Criteria Versus ISTH Criteria
Hayakawa et al.
CLIN APPL THROMB HEMOST 2007;13:172-181.
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Immunomodulatory effects of fosfomycin in an endotoxin model in human blood
Zeitlinger et al.
J Antimicrob Chemother 2007;59:219-223.
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A Prospective Comparative Study of Three Sets of Criteria for Disseminated Intravascular Coagulation: ISTH Criteria vs Japanese Criteria
Hayakawa et al.
CLIN APPL THROMB HEMOST 2007;13:65-72.
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Management of Sepsis
Russell
NEJM 2006;355:1699-1713.
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Modulation of Monocyte Function by Activated Protein C, a Natural Anticoagulant
Stephenson et al.
J. Immunol. 2006;177:2115-2122.
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Pharmacotherapy of Acute Lung Injury and the Acute Respiratory Distress Syndrome
Cepkova and Matthay
J Intensive Care Med 2006;21:119-143.
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Frequency of Abnormal Biphasic aPTT Clot Waveforms in Patients with Underlying Disorders Associated with Disseminated Intravascular Coagulation
Matsumoto et al.
CLIN APPL THROMB HEMOST 2006;12:185-192.
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The Last 100 Years of Sepsis
Vincent and Abraham
Am. J. Respir. Crit. Care Med. 2006;173:256-263.
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Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure
Welty-Wolf et al.
Am. J. Physiol. Lung Cell. Mol. Physiol. 2006;290:L21-L31.
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Effects of Recombinant Human Activated Protein C in Human Models of Endotoxin Administration
Abraham
Proc Am Thorac Soc 2005;2:243-247.
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Disseminated Intravascular Coagulation in Sepsis
Zeerleder et al.
Chest 2005;128:2864-2875.
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Activated Protein C Mediates Novel Lung Endothelial Barrier Enhancement: ROLE OF SPHINGOSINE 1-PHOSPHATE RECEPTOR TRANSACTIVATION
Finigan et al.
J. Biol. Chem. 2005;280:17286-17293.
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Evaluation of New Japanese Diagnostic Criteria for Disseminated Intravascular Coagulation in Critically Ill Patients
Gando et al.
CLIN APPL THROMB HEMOST 2005;11:71-76.
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Activated protein C variants with normal cytoprotective but reduced anticoagulant activity
Mosnier et al.
Blood 2004;104:1740-1744.
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Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium
Chen et al.
Blood 2004;104:1344-1349.
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Evidence-Based Medicine in the ICU: Important Advances and Limitations
Vincent
Chest 2004;126:592-600.
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Evidence-Based Management of Critically Ill Patients: Analysis and Implementation
Gropper
Anesth. Analg. 2004;99:566-572.
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Irwin and Rippe's Intensive Care Medicine
Rice and Ely
JAMA 2004;291:498-499.
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Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia
Kerlin et al.
Blood 2003;102:3085-3092.
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Disseminated intravascular coagulation: old disease, new hope
Toh and Dennis
BMJ 2003;327:974-977.
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Infection and inflammation and the coagulation system
Levi et al.
Cardiovasc Res 2003;60:26-39.
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Efficacy and Safety of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor) in Severe Sepsis: A Randomized Controlled Trial
Abraham et al.
JAMA 2003;290:238-247.
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Unraveling Severe Sepsis: Why Did OPTIMIST Fail and What's Next?
Angus and Crowther
JAMA 2003;290:256-258.
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Reprogramming the Host Response in Bacterial Meningitis: How Best To Improve Outcome?
van der Flier et al.
Clin. Microbiol. Rev. 2003;16:415-429.
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The Hematologic System as a Marker of Organ Dysfunction in Sepsis
Aird
Mayo Clin Proc. 2003;78:869-881.
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The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
Aird
Blood 2003;101:3765-3777.
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The Epidemiology of Sepsis in the United States from 1979 through 2000
Martin et al.
NEJM 2003;348:1546-1554.
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Low-Dose Heparin for Severe Sepsis
Freebairn et al.
NEJM 2003;348:1185-1186.
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A New Paradigm for the Treatment of Sepsis: Is It Time To Consider Combination Therapy?
Cross and Opal
ANN INTERN MED 2003;138:502-505.
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Prevention and Treatment of Acute Renal Failure in Sepsis
De Vriese
J. Am. Soc. Nephrol. 2003;14:792-805.
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The Epidemiology of Severe Sepsis in Children in the United States
Watson et al.
Am. J. Respir. Crit. Care Med. 2003;167:695-701.
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The Pathophysiology and Treatment of Sepsis
Hotchkiss and Karl
NEJM 2003;348:138-150.
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Platelet-Endothelial Interactions: Sepsis, HIT, and Antiphospholipid Syndrome
Warkentin et al.
ASH Education Book 2003;2003:497-519.
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Drotrecogin alfa (activated): a novel therapeutic strategy for severe sepsis
Pastores
Postgrad. Med. J. 2003;79:5-10.
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Risks and Benefits of Activated Protein C Treatment for Severe Sepsis
Warren et al.
NEJM 2002;347:1027-1030.
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Low-Dose Heparin for Severe Sepsis
Davidson et al.
NEJM 2002;347:1036-1037.
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Editorial III: Inflammation and the coagulation system
Webster
Br J Anaesth 2002;89:216-220.
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Antithrombin III inhibits nuclear factor kappa B activation in human monocytes and vascular endothelial cells
Oelschlager et al.
Blood 2002;99:4015-4020.
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Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice
Yanada et al.
Blood 2002;99:2455-2458.
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Goal-Directed Therapy for Severe Sepsis
Marik et al.
NEJM 2002;346:1025-1026.
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Use of Anticoagulants in Patients With Sepsis
Langer et al.
JAMA 2002;287:448-449.
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Coagulation: Consultative Hemostasis
Hambleton et al.
ASH Education Book 2002;2002:335-352.
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Continuing Challenges of Sepsis Research
Crowther and Marshall
JAMA 2001;286:1894-1896.
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