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Terminology for Reporting Results of Cervical Cytology

Diane Solomon, MD; Diane Davey, MD; Robert Kurman, MD; Ann Moriarty, MD; Dennis O'Connor, MD; Marianne Prey, MD; Stephen Raab, MD; Mark Sherman, MD; David Wilbur, MD; Thomas Wright, Jr, MD; Nancy Young, MD; for the Forum Group Members and the Bethesda 2001 Workshop

JAMA. 2002;287:2114-2119.

Objectives  The Bethesda 2001 Workshop was convened to evaluate and update the 1991 Bethesda System terminology for reporting the results of cervical cytology. A primary objective was to develop a new approach to broaden participation in the consensus process.

Participants  Forum groups composed of 6 to 10 individuals were responsible for developing recommendations for discussion at the workshop. Each forum group included at least 1 cytopathologist, cytotechnologist, clinician, and international representative to ensure a broad range of views and interests. More than 400 cytopathologists, cytotechnologists, histopathologists, family practitioners, gynecologists, public health physicians, epidemiologists, patient advocates, and attorneys participated in the workshop, which was convened by the National Cancer Institute and cosponsored by 44 professional societies. More than 20 countries were represented.

Evidence  Literature review, expert opinion, and input from an Internet bulletin board were all considered in developing recommendations. The strength of evidence of the scientific data was considered of paramount importance.

Consensus Process  Bethesda 2001 was a year-long iterative review process. An Internet bulletin board was used for discussion of issues and drafts of recommendations. More than 1000 comments were posted to the bulletin board over the course of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to the public. Postworkshop recommendations were posted on the bulletin board for a last round of critical review prior to finalizing the terminology.

Conclusions  Bethesda 2001 was developed with broad participation in the consensus process. The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.

Author Affiliations: Division of Cancer Prevention, National Cancer Institute, Bethesda, Md (Dr Solomon); Department of Pathology and Laboratory Medicine, University of Kentucky Medical Center, Lexington (Dr Davey); Departments of Gynecology and Obstetrics and Pathology, Johns Hopkins Hospital, Baltimore, Md (Dr Kurman); AmeriPath Indiana, Indianapolis (Dr Moriarty); Clinical Pathology Associates, Louisville, Ky (Dr O'Connor); Quest Diagnostics Incorporated, St Louis, Mo (Dr Prey); Department of Pathology, Allegheny Hospital, Pittsburgh, Pa (Dr Raab); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md (Dr Sherman); Department of Pathology, Massachusetts General Hospital, Boston (Dr Wilbur); Department of Pathology, Columbia University, New York, NY (Dr Wright); and Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pa (Dr Young).

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