Hyperhomocysteinemia and Lower Extremity Wounds
Schwartzfarb and Romanelli
INT J LOW EXTREM WOUNDS 2008;7:126-136.
ABSTRACT
Murine Models of Hyperhomocysteinemia and Their Vascular Phenotypes
Dayal and Lentz
Arterioscler. Thromb. Vasc. Bio. 2008;28:1596-1605.
ABSTRACT
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Genetic Predisposition, Nongenetic Risk Factors, and Coronary Infarct
Trichopoulou et al.
Arch Intern Med 2008;168:891-896.
ABSTRACT
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Folate, Vitamin B6, Vitamin B12, and Methionine Intakes and Risk of Stroke Subtypes in Male Smokers
Larsson et al.
Am J Epidemiol 2008;167:954-961.
ABSTRACT
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Cardiac Autonomic Dysfunction: Effects From Particulate Air Pollution and Protection by Dietary Methyl Nutrients and Metabolic Polymorphisms
Baccarelli et al.
Circulation 2008;117:1802-1809.
ABSTRACT
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Lowering Plasma Homocysteine Concentrations of Older Men and Women with Folate, Vitamin B-12, and Vitamin B-6 Does Not Affect the Proportion of (n-3) Long Chain Polyunsaturated Fatty Acids in Plasma Phosphatidylcholine
Crowe et al.
J. Nutr. 2008;138:551-555.
ABSTRACT
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Meta- and Pooled Analyses of the Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Gastric Cancer Risk: A Huge-GSEC Review
Boccia et al.
Am J Epidemiol 2008;167:505-516.
ABSTRACT
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Homocysteine lowering with folic acid and B vitamins in people with chronic kidney disease--results of the renal Hope-2 study
Mann et al.
Nephrol Dial Transplant 2008;23:645-653.
ABSTRACT
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B Vitamins for the Prevention of Vascular Disease: Insufficient Evidence to Justify Treatment
Baigent and Clarke
JAMA 2007;298:1212-1214.
FULL TEXT
Summary of the American Heart Association's Scientific Statement on the Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease
Arnett and for the Writing Group
Arterioscler. Thromb. Vasc. Bio. 2007;27:1682-1686.
FULL TEXT
The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway
Siva et al.
QJM 2007;100:495-499.
ABSTRACT
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High frequency of vitamin B12 deficiency in asymptomatic individuals homozygous to MTHFR C677T mutation is associated with endothelial dysfunction and homocysteinemia
Zittan et al.
Am. J. Physiol. Heart Circ. Physiol. 2007;293:H860-H865.
ABSTRACT
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Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease: A Scientific Statement From the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group
Arnett et al.
Circulation 2007;115:2878-2901.
ABSTRACT
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Homocysteine and Cardiovascular Risk: Considering the Evidence in the Context of Study Design, Folate Fortification, and Statistical Power
Ueland and Clarke
Clin. Chem. 2007;53:807-809.
FULL TEXT
Lowering Homocysteine with B Vitamins Has No Effect on Blood Pressure in Older Adults
McMahon et al.
J. Nutr. 2007;137:1183-1187.
ABSTRACT
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Genetic Effects versus Bias for Candidate Polymorphisms in Myocardial Infarction: Case Study and Overview of Large-Scale Evidence
Ntzani et al.
Am J Epidemiol 2007;165:973-984.
ABSTRACT
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Homocysteine, 5,10-Methylenetetrahydrofolate Reductase 677C>T Polymorphism, Nutrient Intake, and Incident Cardiovascular Disease in 24 968 Initially Healthy Women
Zee et al.
Clin. Chem. 2007;53:845-851.
ABSTRACT
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Nonvalidation of Reported Genetic Risk Factors for Acute Coronary Syndrome in a Large-Scale Replication Study
Morgan et al.
JAMA 2007;297:1551-1561.
ABSTRACT
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Effect of MTHFR C677T genotype on survival in type 2 diabetes patients with end-stage diabetic nephropathy
Boger et al.
Nephrol Dial Transplant 2007;22:154-162.
ABSTRACT
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Elevated Prenatal Homocysteine Levels as a Risk Factor for Schizophrenia
Brown et al.
Arch Gen Psychiatry 2007;64:31-39.
ABSTRACT
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Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial
den Heijer et al.
Blood 2007;109:139-144.
ABSTRACT
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Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence
Wald et al.
BMJ 2006;333:1114-1117.
FULL TEXT
Alleviating the Burden of Cancer: A Perspective on Advances, Challenges, and Future Directions.
Schottenfeld and Beebe-Dimmer
Cancer Epidemiol. Biomarkers Prev. 2006;15:2049-2055.
ABSTRACT
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Stromelysin-1 5A/6A and eNOS T-786C Polymorphisms, MTHFR C677T and A1298C Mutations, and Cigarette-Cannabis Smoking: A Pilot, Hypothesis-Generating Study of Gene-Environment Pathophysiological Associations With Buerger's Disease.
Glueck et al.
CLIN APPL THROMB HEMOST 2006;12:427-439.
ABSTRACT
Interaction of homocysteine and conventional predisposing factors on risk of ischaemic stroke in young people: consistency in phenotype-disease analysis and genotype-disease analysis
Pezzini et al.
J. Neurol. Neurosurg. Psychiatry 2006;77:1150-1156.
ABSTRACT
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Homocysteine Hypothesis for Atherothrombotic Cardiovascular Disease: Not Validated
Kaul et al.
J Am Coll Cardiol 2006;48:914-923.
ABSTRACT
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Insight into the nature of the CRP-coronary event association using Mendelian randomization
Casas et al.
Int J Epidemiol 2006;35:922-931.
ABSTRACT
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Response to Letter Regarding Article, "Riboflavin Lowers Homocysteine in Individuals Homozygous for the MTHFR 677C->T Polymorphism"
McNulty et al.
Circulation 2006;114:e66-e66.
FULL TEXT
Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: A randomized controlled study
Postuma et al.
Neurology 2006;66:1941-1943.
ABSTRACT
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The Many Facets of Hyperhomocysteinemia: Studies from the Framingham Cohorts
Selhub
J. Nutr. 2006;136:1726S-1730S.
ABSTRACT
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The Hordaland Homocysteine Study: A Community-Based Study of Homocysteine, Its Determinants, and Associations with Disease
Refsum et al.
J. Nutr. 2006;136:1731S-1740S.
ABSTRACT
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Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
The Heart Outcomes Prevention Evaluation (HOPE) 2
NEJM 2006;354:1567-1577.
ABSTRACT
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Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation
van Beynum et al.
Eur Heart J 2006;27:981-987.
ABSTRACT
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Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population
Devlin et al.
Am. J. Clin. Nutr. 2006;83:708-713.
ABSTRACT
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Methylenetetrahydrofolate Reductase Polymorphisms and Homocysteine-Lowering Effect of Vitamin Therapy in Singaporean Stroke Patients
Ho et al.
Stroke 2006;37:456-460.
ABSTRACT
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Riboflavin Lowers Homocysteine in Individuals Homozygous for the MTHFR 677C->T Polymorphism
McNulty et al.
Circulation 2006;113:74-80.
ABSTRACT
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The Glycine N-Methyltransferase (GNMT) 1289 C->T Variant Influences Plasma Total Homocysteine Concentrations in Young Women after Restricting Folate Intake
Beagle et al.
J. Nutr. 2005;135:2780-2785.
ABSTRACT
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The choice of a genetic model in the meta-analysis of molecular association studies
Minelli et al.
Int J Epidemiol 2005;34:1319-1328.
ABSTRACT
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JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice
Prepared by: British Cardiac Society, British Hype
Heart 2005;91:v1-v52.
FULL TEXT
Homocysteine and Its Effects on In-Stent Restenosis
De Luca et al.
Circulation 2005;112:e307-e311.
FULL TEXT
Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?
Lewis et al.
BMJ 2005;331:1053.
ABSTRACT
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Homocysteine Levels, MTHFR C677T Genotype, and MRI Hyperintensities in Late-Onset Major Depressive Disorder
Chen et al.
AJGP 2005;13:869-875.
ABSTRACT
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Assessment of Hemostatic Risk Factors in Predicting Arterial Thrombotic Events
Feinbloom and Bauer
Arterioscler. Thromb. Vasc. Bio. 2005;25:2043-2053.
ABSTRACT
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A high-protein diet increases postprandial but not fasting plasma total homocysteine concentrations: a dietary controlled, crossover trial in healthy volunteers
Verhoef et al.
Am. J. Clin. Nutr. 2005;82:553-558.
ABSTRACT
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Review: Diabetes and cardiac disease in South Asians
Mukhopadhyay et al.
British Journal of Diabetes & Vascular Disease 2005;5:253-259.
ABSTRACT
Cerebral Vascular Dysfunction in Methionine Synthase-Deficient Mice
Dayal et al.
Circulation 2005;112:737-744.
ABSTRACT
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Polymorphisms in Cytoplasmic Serine Hydroxymethyltransferase and Methylenetetrahydrofolate Reductase Affect the Risk of Cardiovascular Disease in Men
Lim et al.
J. Nutr. 2005;135:1989-1994.
ABSTRACT
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Alcohol intake and methylenetetrahydrofolate reductase polymorphism modify the relation of folate intake to plasma homocysteine
Chiuve et al.
Am. J. Clin. Nutr. 2005;82:155-162.
ABSTRACT
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Homocysteine and MTHFR Mutations: Relation to Thrombosis and Coronary Artery Disease
Varga et al.
Circulation 2005;111:e289-e293.
FULL TEXT
Hyperhomocysteinemic Diabetic Cardiomyopathy: Oxidative Stress, Remodeling, and Endothelial-Myocyte Uncoupling
Tyagi et al.
J CARDIOVASC PHARMACOL THER 2005;10:1-10.
ABSTRACT
Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study
Frederiksen et al.
Blood 2004;104:3046-3051.
ABSTRACT
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Folate levels determine effect of antioxidant supplementation on micronuclei in subjects with cardiovascular risk
Smolkova et al.
Mutagenesis 2004;19:469-476.
ABSTRACT
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Meta-analysis of Genetic Studies in Ischemic Stroke: Thirty-two Genes Involving Approximately 18 000 Cases and 58 000 Controls
Casas et al.
Arch Neurol 2004;61:1652-1661.
ABSTRACT
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Genetic Basis of Atherosclerosis: Part II: Clinical Implications
Lusis et al.
Circulation 2004;110:2066-2071.
FULL TEXT
Phenotypic expression of the methylenetetrahydrofolate reductase 677C->T polymorphism and flavin cofactor availability in thyroid dysfunction
Hustad et al.
Am. J. Clin. Nutr. 2004;80:1050-1057.
ABSTRACT
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Homocysteine and levodopa: Should Parkinson disease patients receive preventative therapy?
Postuma and Lang
Neurology 2004;63:886-891.
ABSTRACT
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Dietary serine and cystine attenuate the homocysteine-raising effect of dietary methionine: a randomized crossover trial in humans
Verhoef et al.
Am. J. Clin. Nutr. 2004;80:674-679.
ABSTRACT
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Bioavailability of polyglutamyl folic acid relative to that of monoglutamyl folic acid in subjects with different genotypes of the glutamate carboxypeptidase II gene
Melse-Boonstra et al.
Am. J. Clin. Nutr. 2004;80:700-704.
ABSTRACT
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An Integrated Approach to the Meta-Analysis of Genetic Association Studies using Mendelian Randomization
Minelli et al.
Am J Epidemiol 2004;160:445-452.
ABSTRACT
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Hyperhomocysteinemia in Patients with Cushing's Syndrome
Terzolo et al.
J. Clin. Endocrinol. Metab. 2004;89:3745-3751.
ABSTRACT
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Folic Acid-Based Multivitamin Therapy to Prevent Stroke: The Jury Is Still Out
Hankey and Eikelboom
Stroke 2004;35:1995-1998.
FULL TEXT
Established and Emerging Plasma Biomarkers in the Prediction of First Atherothrombotic Events
Ridker et al.
Circulation 2004;109:IV-6-IV-19.
FULL TEXT
5,10-methylenetetrahydrofolate reductase (MTHFR) 677C->T and 1298A->C mutations are associated with DNA hypomethylation
Castro et al.
J. Med. Genet. 2004;41:454-458.
FULL TEXT
A healthy lifestyle lowers homocysteine, but should we care?
Verhoef and Katan
Am. J. Clin. Nutr. 2004;79:713-714.
FULL TEXT
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice
Devlin et al.
Blood 2004;103:2624-2629.
ABSTRACT
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Cross-talk between Cys34 and Lysine Residues in Human Serum Albumin Revealed by N-Homocysteinylation
Glowacki and Jakubowski
J. Biol. Chem. 2004;279:10864-10871.
ABSTRACT
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Polymorphisms in Genes Involved in Folate Metabolism and Colorectal Neoplasia: A HuGE Review
Sharp and Little
Am J Epidemiol 2004;159:423-443.
ABSTRACT
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Commentary: Mendelian randomization, 18 years on
Katan
Int J Epidemiol 2004;33:10-11.
FULL TEXT
Mendelian randomization: prospects, potentials, and limitations
Smith and Ebrahim
Int J Epidemiol 2004;33:30-42.
FULL TEXT
Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion
Refsum et al.
Clin. Chem. 2004;50:3-32.
ABSTRACT
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Red cell N5-methyltetrahydrofolate concentrations and C677T methylenetetrahydrofolate reductase genotype in patients with stroke
Icke et al.
J. Clin. Pathol. 2004;57:54-57.
ABSTRACT
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The atherogenic effect of excess methionine intake
Troen et al.
Proc. Natl. Acad. Sci. USA 2003;100:15089-15094.
ABSTRACT
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Controlled Modulation of Folate Polyglutamyl Tail Length by Metabolic Engineering of Lactococcus lactis
Sybesma et al.
Appl. Environ. Microbiol. 2003;69:7101-7107.
ABSTRACT
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Low Dose Betaine Supplementation Leads to Immediate and Long Term Lowering of Plasma Homocysteine in Healthy Men and Women
Olthof et al.
J. Nutr. 2003;133:4135-4138.
ABSTRACT
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Homocysteine Status and Polymorphisms of Methylenetetrahydrofolate Reductase Are Not Associated With Restenosis After Stenting in Coronary Arteries
Koch et al.
Arterioscler. Thromb. Vasc. Bio. 2003;23:2229-2234.
ABSTRACT
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Age and Gender Affect the Relation between Methylenetetrahydrofolate Reductase C677T Genotype and Fasting Plasma Homocysteine Concentrations in the Framingham Offspring Study Cohort
Russo et al.
J. Nutr. 2003;133:3416-3421.
ABSTRACT
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Colon Cancer and Genetic Variation in Folate Metabolism: The Clinical Bottom Line
Little et al.
J. Nutr. 2003;133:3758S-3766.
ABSTRACT
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Homocysteine and the Risk of Intrauterine Growth Retardation
Cattaneo
Clin. Chem. 2003;49:1432-1433.
FULL TEXT
The Use of B Vitamin Supplements and Peripheral Arterial Disease Risk in Men Are Inversely Related
Merchant et al.
J. Nutr. 2003;133:2863-2867.
ABSTRACT
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Elevated Plasma Homocysteine Was Associated With Hemorrhagic and Ischemic Stroke, but Methylenetetrahydrofolate Reductase Gene C677T Polymorphism Was a Risk Factor for Thrombotic Stroke: A Multicenter Case-Control Study in China
Li et al.
Stroke 2003;34:2085-2090.
ABSTRACT
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Emerging Risk Factors for Atherosclerotic Vascular Disease: A Critical Review of the Evidence
Hackam and Anand
JAMA 2003;290:932-940.
ABSTRACT
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Influence of Centrifugation Temperature on the Plasma Total Homocysteine Concentration
de Bree et al.
Clin. Chem. 2003;49:1026-1027.
FULL TEXT
Folate and risk of cardiovascular disease
Wald et al.
BMJ 2003;326:1035-1035.
FULL TEXT
ADDITIONAL ARTICLES ABSTRACTED IN ACP JOURNAL CLUB
Evid. Based Med. 2003;8:67-67.
FULL TEXT
Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study
van Oort et al.
Am. J. Clin. Nutr. 2003;77:1318-1323.
ABSTRACT
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Effect of Glutamate Carboxypeptidase II and Reduced Folate Carrier Polymorphisms on Folate and Total Homocysteine Concentrations in Dialysis Patients
Fodinger et al.
J. Am. Soc. Nephrol. 2003;14:1314-1319.
ABSTRACT
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The Interaction between MTHFR 677 C->T Genotype and Folate Status Is a Determinant of Coronary Atherosclerosis Risk
Girelli et al.
J. Nutr. 2003;133:1281-1285.
ABSTRACT
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'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?
Davey Smith and Ebrahim
Int J Epidemiol 2003;32:1-22.
ABSTRACT
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Commentary: Colon cancer, folate and genetic status
Fallon
Int J Epidemiol 2003;32:67-70.
FULL TEXT
Is Widespread Homocysteine Screening Worth It?
Journal Watch Cardiology 2003;2003:1-1.
FULL TEXT