You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT JAMA
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 288 No. 24, December 25, 2002 TABLE OF CONTENTS
  JAMA
  •  Online Features
  Original Contribution
 This Article
 •Full text
 •PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on ISI (64)
 •Contact me when this article is cited
 Related Content
 •Similar articles in JAMA
 Topic Collections
 •Men's Health, Other
 •Neurology
 •Cerebrovascular Disease
 •Stroke
 •Lipids and Lipid Disorders
 •Alert me on articles by topic

Fish Consumption and Risk of Stroke in Men

Ka He, MD, MPH; Eric B. Rimm, ScD; Anwar Merchant, DMD, ScD; Bernard A. Rosner, PhD; Meir J. Stampfer, MD, DrPH; Walter C. Willett, MD, DrPH; Alberto Ascherio, MD, DrPH

JAMA. 2002;288:3130-3136.

Context  The effect of fish consumption or long-chain omega-3 polyunsaturated fatty acid (PUFA) intake on risk of stroke remains uncertain.

Objective  To examine the relation of fish consumption and long-chain omega-3 PUFA intake and risk of stroke in men.

Design and Setting  The Health Professional Follow-up Study, a US prospective cohort study with 12 years of follow-up.

Participants  A total of 43 671 men aged 40 to 75 years who completed a detailed and validated semiquantitative food frequency questionnaire and who were free of cardiovascular disease at baseline in 1986.

Main Outcome Measure  Relative risk (RR) of stroke by subtype based on cumulative average fish consumption or long-chain omega-3 PUFA intake, ascertained in 1986, 1990, and 1994.

Results  We documented 608 strokes during the 12-year follow-up period, including 377 ischemic, 106 hemorrhagic, and 125 unclassified strokes. Compared with men who consumed fish less than once per month, the multivariate RR of ischemic stroke was significantly lower among those who ate fish 1 to 3 times per month (RR, 0.57; 95% confidence interval [CI], 0.35-0.95). However, a higher frequency of fish intake was not associated with further risk reduction; the RR was 0.54 (95% CI, 0.31-0.94) for men who consumed fish 5 or more times per week. This lack of linearity was confirmed by spline analyses. By dichotomized fish intake, the multivariate RR for men who consumed fish at least once per month compared with those who ate fish less than once per month was 0.56 (95% CI, 0.38-0.83) for ischemic stroke and 1.36 (95% CI, 0.48-3.82) for hemorrhagic stroke. The inverse association between fish intake and risk of ischemic stroke was not materially modified by use of aspirin. No significant associations were found between fish or long-chain omega-3 PUFA intake and risk of hemorrhagic stroke.

Conclusion  Our findings suggest that eating fish once per month or more can reduce the risk of ischemic stroke in men.


Author Affiliations: Departments of Nutrition (Drs He, Rimm, Merchant, Stampfer, Willett, and Ascherio), Epidemiology (Drs Rimm, Stampfer, Willett, and Ascherio), and Biostatistics (Dr Rosner), Harvard School of Public Health, and the Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School (Drs Rimm, Rosner, Stampfer, Willett, and Ascherio), Boston, Mass.



THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Intakes of long-chain n-3 polyunsaturated fatty acids and fish in relation to measurements of subclinical atherosclerosis
He et al.
Am. J. Clin. Nutr. 2008;88:1111-1118.
ABSTRACT | FULL TEXT  

Fish, {omega}-3 Polyunsaturated Fatty Acids, and Mortality From Cardiovascular Diseases in a Nationwide Community-Based Cohort of Japanese Men and Women: The JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) Study
Yamagishi et al.
J Am Coll Cardiol 2008;52:988-996.
ABSTRACT | FULL TEXT  

Long-chain n-3 fatty acids and mortality in elderly patients
Lindberg et al.
Am. J. Clin. Nutr. 2008;88:722-729.
ABSTRACT | FULL TEXT  

Fish consumption and risk of subclinical brain abnormalities on MRI in older adults
Virtanen et al.
Neurology 2008;71:439-446.
ABSTRACT | FULL TEXT  

Consumption of cured meats and prospective risk of chronic obstructive pulmonary disease in women
Jiang et al.
Am. J. Clin. Nutr. 2008;87:1002-1008.
ABSTRACT | FULL TEXT  

Cardiovascular benefits of omega-3 fatty acids
von Schacky and Harris
Cardiovasc Res 2007;73:310-315.
ABSTRACT | FULL TEXT  

Metabolic Risk Factors for Stroke and Transient Ischemic Attacks in Middle-Aged Men: A Community-Based Study With Long-Term Follow-Up
Wiberg et al.
Stroke 2006;37:2898-2903.
ABSTRACT | FULL TEXT  

Current Clinical Applications of {Omega}-6 and {Omega}-3 Fatty Acids
Lee et al.
Nutr Clin Pract 2006;21:323-341.
ABSTRACT | FULL TEXT  

Healthy lifestyle and the risk of stroke in women.
Kurth et al.
Arch Intern Med 2006;166:1403-1409.
ABSTRACT | FULL TEXT  

n-3 Fatty acids from fish or fish-oil supplements, but not {alpha}-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
Wang et al.
Am. J. Clin. Nutr. 2006;84:5-17.
ABSTRACT | FULL TEXT  

Cigarette Smoking, Fish Consumption, Omega-3 Fatty Acid Intake, and Associations With Age-Related Macular Degeneration: The US Twin Study of Age-Related Macular Degeneration
Seddon et al.
Arch Ophthalmol 2006;124:995-1001.
ABSTRACT | FULL TEXT  

Theme Issue on Men's Health: Call for Papers
Fontanarosa and Cole
JAMA 2006;295:440-441.
FULL TEXT  

Managing Abnormal Blood Lipids: A Collaborative Approach
Fletcher et al.
Circulation 2005;112:3184-3209.
ABSTRACT | FULL TEXT  

Intake of n-6 and n-3 fatty acids and fish and risk of community-acquired pneumonia in US men
Merchant et al.
Am. J. Clin. Nutr. 2005;82:668-674.
ABSTRACT | FULL TEXT  

Long-chain n-3 polyunsaturated fatty acids in plasma in British meat-eating, vegetarian, and vegan men
Rosell et al.
Am. J. Clin. Nutr. 2005;82:327-334.
ABSTRACT | FULL TEXT  

Firearm Violence Exposure and Serious Violent Behavior
Bingenheimer et al.
Science 2005;308:1323-1326.
ABSTRACT | FULL TEXT  

Fish Consumption and Stroke Risk in Elderly Individuals: The Cardiovascular Health Study
Mozaffarian et al.
Arch Intern Med 2005;165:200-206.
ABSTRACT | FULL TEXT  

Alcohol and Risk for Ischemic Stroke in Men: The Role of Drinking Patterns and Usual Beverage
Mukamal et al.
ANN INTERN MED 2005;142:11-19.
ABSTRACT | FULL TEXT  

Practical Applications of Fish Oil ({Omega}-3 Fatty Acids) in Primary Care
Oh
J Am Board Fam Med 2005;18:28-36.
ABSTRACT | FULL TEXT  

Prospective Study of Major Dietary Patterns and Stroke Risk in Women
Fung et al.
Stroke 2004;35:2014-2019.
ABSTRACT | FULL TEXT  

Fish Consumption and Incidence of Stroke: A Meta-Analysis of Cohort Studies
He et al.
Stroke 2004;35:1538-1542.
ABSTRACT | FULL TEXT  

Role of Omega-3 Fatty Acid Supplementation in Inflammation and Malignancy
Jho et al.
Integr Cancer Ther 2004;3:98-111.
ABSTRACT  

Folate, Vitamin B6, and B12 Intakes in Relation to Risk of Stroke Among Men
He et al.
Stroke 2004;35:169-174.
ABSTRACT | FULL TEXT  

Dietary fat intake and risk of stroke in male US healthcare professionals: 14 year prospective cohort study
He et al.
BMJ 2003;327:777-782.
ABSTRACT | FULL TEXT  

Commentary: Protection from stroke by eating animal foods? Surely not!
Fraser
Int J Epidemiol 2003;32:543-545.
FULL TEXT  

Fish Consumption and the Risk of Alzheimer Disease: Is It Time to Make Dietary Recommendations?
Friedland
Arch Neurol 2003;60:923-924.
FULL TEXT  

From the Library
Br. J. Ophthalmol. 2003;87:378-378.
FULL TEXT  

Eating Fish Might Reduce Stroke Risk
Journal Watch Dermatology 2003;2003:10-10.
FULL TEXT  

Just a Bit of Fish May Be Enough to Reduce Stroke Risk in Men
Journal Watch Cardiology 2003;2003:2-2.
FULL TEXT  

Eating Fish Reduces Ischemic Stroke Risk
JWatch Emergency Med. 2003;2003:5-5.
FULL TEXT  

Eating Fish Might Reduce Stroke Risk
JWatch General 2003;2003:4-4.
FULL TEXT  

Organic mercury compounds: human exposure and its relevance to public health
Risher et al.
Toxicol Ind Health 2002;18:109-160.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 2002 American Medical Association. All Rights Reserved.