 |
 |

Maternal Immunity and Prevention of Congenital Cytomegalovirus Infection
Karen B. Fowler, DrPH;
Sergio Stagno, MD;
Robert F. Pass, MD
JAMA. 2003;289:1008-1011.
Context Vaccine development to prevent congenital cytomegalovirus (CMV) infection has been impeded by the uncertainty over whether maternal immunity protects the fetus.
Objective To determine whether the presence of maternal antibodies to CMV significantly reduces the risk of congenital CMV infection in future pregnancies.
Design, Setting, and Participants Cohort study of 3461 multiparous women from a population with a high rate of congenital CMV infection who delivered newborns screened for congenital CMV infection between 1993 and 1998, and whose cord serum specimen from a previous delivery could be retrieved and tested for antibody to CMV.
Main Outcome Measure Congenital CMV infection according to maternal immune status, age, race, parity, and socioeconomic status.
Results Of 604 newborns born to initially seronegative mothers, congenital CMV infection occurred in 18 (3.0%). In contrast, of 2857 newborns born to immune mothers, congenital CMV infection occurred in 29 (1.0%) Two factors, preconception maternal immunity (adjusted risk ratio, 0.31; 95% confidence interval, 0.17-0.58) and maternal age of 25 years or older (adjusted risk ratio, 0.19; 95% confidence interval, 0.07-0.49), were highly protective against congenital CMV infection. No other factors were associated with a reduction in the risk of congenital CMV infection.
Conclusion Naturally acquired immunity results in a 69% reduction in the risk of congenital CMV infection in future pregnancies.
Author Affiliations: Departments of Pediatrics (Drs Fowler, Stagno, and Pass), Epidemiology (Dr Fowler), Maternal and Child Health (Dr Fowler), and Microbiology (Drs Stagno and Pass), University of Alabama, Birmingham.
RELATED LETTER
Natural vs Vaccine-Acquired Immunity to Cytomegalovirus
Stanley A. Plotkin
JAMA. 2003;290(13):1709.
EXTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
 |
Human cytomegalovirus serum neutralizing antibodies block virus infection of endothelial/epithelial cells, but not fibroblasts, early during primary infection
Gerna et al.
J. Gen. Virol. 2008;89:853-865.
ABSTRACT
| FULL TEXT
Targeted Deletion of Regions Rich in Immune-Evasive Genes from the Cytomegalovirus Genome as a Novel Vaccine Strategy
Cicin-Sain et al.
J. Virol. 2007;81:13825-13834.
ABSTRACT
| FULL TEXT
Hepatitis B Virus Translocates across a Trophoblastic Barrier
Bhat and Anderson
J. Virol. 2007;81:7200-7207.
ABSTRACT
| FULL TEXT
Developmental Regulation of Human Cytomegalovirus Receptors in Cytotrophoblasts Correlates with Distinct Replication Sites in the Placenta
Maidji et al.
J. Virol. 2007;81:4701-4712.
ABSTRACT
| FULL TEXT
Cytomegalovirus Infections
Adler and Marshall
Pediatr. Rev. 2007;28:92-100.
FULL TEXT
National Serosurvey of Cytomegalovirus in Australia
Seale et al.
CVI 2006;13:1181-1184.
ABSTRACT
| FULL TEXT
Mixed infection with multiple strains of murine cytomegalovirus occurs following simultaneous or sequential infection of immunocompetent mice.
Gorman et al.
J. Gen. Virol. 2006;87:1123-1132.
ABSTRACT
| FULL TEXT
Neonatal Innate Immunity to Infectious Agents
Marodi
Infect. Immun. 2006;74:1999-2006.
FULL TEXT
Passive immunization during pregnancy for congenital cytomegalovirus infection.
Nigro et al.
NEJM 2005;353:1350-1362.
ABSTRACT
| FULL TEXT
Immunotherapy for congenital cytomegalovirus infection.
Duff
NEJM 2005;353:1402-1404.
FULL TEXT
Diagnosis of and Screening for Cytomegalovirus Infection in Pregnant Women
Munro et al.
J. Clin. Microbiol. 2005;43:4713-4718.
ABSTRACT
| FULL TEXT
Systemic Priming-Boosting Immunization with a Trivalent Plasmid DNA and Inactivated Murine Cytomegalovirus (MCMV) Vaccine Provides Long-Term Protection against Viral Replication following Systemic or Mucosal MCMV Challenge
Morello et al.
J. Virol. 2005;79:159-175.
ABSTRACT
| FULL TEXT
Natural vs Vaccine-Acquired Immunity to Cytomegalovirus
Plotkin
JAMA 2003;290:1709-1709.
FULL TEXT
The Role of Prior Maternal CMV Immunity in Congenital CMV
JWatch Pediatrics 2003;2003:4-4.
FULL TEXT
|