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Nina S. Kadan-Lottick, MD, MSPH; Kirsten K. Ness, MPH; Smita Bhatia, MD, MPH; James G. Gurney, PhD

JAMA. 2003;290:2008-2014.

Context  The role of race/ethnicity in survival of children with acute lymphoblastic leukemia (ALL) is unclear, with some studies reporting poorer survival among minority children and others reporting equivalent survival across race/ethnicity in the modern, risk-stratified treatment era.

Objective  To investigate the relation between race/ethnicity and survival in a large, population-based analysis of incident ALL cases in the United States.

Design, Population, and Setting  This study included 4952 individuals diagnosed with ALL between 1973 and 1999 at age 19 years or younger. ALL cases were identified from 9 population-based registries of the National Cancer Institute's Surveillance, Epidemiology, and End Results program.

Main Outcome Measures  Survival probabilities were compared among white, black, Hispanic, Asian/Pacific Islander, and American Indian/Alaskan Native children. Kaplan-Meier curves and proportional hazard ratios from Cox regression analysis were calculated, accounting for treatment era (1973-1982, 1983-1989, and 1990-1999), age at diagnosis (<1, 1-9, and 10-19 years), and sex.

Results  Although overall 5-year survival probabilities improved with each successive treatment era, differences according to race/ethnicity persisted. For 1990-1999, 5-year survival was 84% for white children, 81% for Asian/Pacific Islander children, 75% for black children, and 72% for both American Indian/Alaskan Native children and Hispanic children. The largest difference by race/ethnicity was observed among children diagnosed between ages 1 and 9 years. Compared with white children, after adjusting for treatment era, age at diagnosis, and sex, children of black, Hispanic, and American Indian/Alaskan Native descent had hazard ratios of 1.50 (95% CI, 1.0-2.2; P = .03), 1.83 (95% CI, 1.4-2.4; P<.001), and 1.90 (95% CI, 0.8-4.6; P = .16).

Conclusions  Black, Hispanic, and American Indian/Alaskan Native children with ALL have worse survival than white and Asian/Pacific Islander children, even in the contemporary treatment era. Future work must delineate the social and biological factors, including any differences in pharmacokinetics associated with chemotherapeutic agents, that account for disparities in outcome.

Author Affiliations: Division of Pediatric Hematology/Oncology, Yale University, New Haven, Conn (Dr Kadan-Lottick); Division of Pediatric Epidemiology and Clinical Research, University of Minnesota, Minneapolis (Ms Ness and Dr Gurney); Division of Pediatrics, City of Hope National Medical Center, Duarte, Calif (Dr Bhatia).

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