This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (363)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Topic Collections  • Men's Health, Other  • Lipids and Lipid Disorders  • Cardiovascular Disease/ Myocardial Infarction  • Alert me on articles by topic

Tobias Pischon, MD, MPH; Cynthia J. Girman, DrPH; Gokhan S. Hotamisligil, MD, PhD; Nader Rifai, PhD; Frank B. Hu, MD, PhD; Eric B. Rimm, ScD

JAMA. 2004;291:1730-1737.

Context  Adiponectin, a recently discovered adipocyte-derived peptide, is involved in the regulation of insulin sensitivity and lipid oxidation and, purportedly, in the development of atherosclerosis and coronary heart disease in humans.

Objective  To assess prospectively whether plasma adiponectin concentrations are associated with risk of myocardial infarction (MI).

Design, Setting, and Participants  Nested case-control study among 18 225 male participants of the Health Professionals Follow-up Study aged 40 to 75 years who were free of diagnosed cardiovascular disease at the time of blood draw (1993-1995). During 6 years of follow-up through January 31, 2000, 266 men subsequently developed nonfatal MI or fatal coronary heart disease. Using risk set sampling, controls were selected in a 2:1 ratio matched for age, date of blood draw, and smoking status (n = 532).

Main Outcome Measure  Incidence of nonfatal MI and fatal coronary heart disease by adiponectin level.

Results  After adjustment for matched variables, participants in the highest compared with the lowest quintile of adiponectin levels had a significantly decreased risk of MI (relative risk [RR], 0.39; 95% confidence interval [CI], 0.23-0.64; P for trend <.001). Additional adjustment for family history of MI, body mass index, alcohol consumption, physical activity, and history of diabetes and hypertension did not substantively affect this relationship (RR, 0.41; 95% CI, 0.24-0.70; P for trend <.001). Further adjustment for hemoglobin A_1c or C-reactive protein levels also had little impact, but additional adjustment for low- and high-density lipoprotein cholesterol levels modestly attenuated this association (RR, 0.56; 95% CI, 0.32-0.99; P for trend = .02).

Conclusions  High plasma adiponectin concentrations are associated with lower risk of MI in men. This relationship can be only partly explained by differences in blood lipids and is independent of inflammation and glycemic status.

Author Affiliations: Departments of Nutrition (Drs Pischon, Hotamisligil, Hu, and Rimm) and Epidemiology (Drs Pischon, Hu, and Rimm), Harvard School of Public Health, Channing Laboratory, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School (Drs Hu and Rimm), Department of Laboratory Medicine, Children's Hospital (Dr Rifai), and Department of Pathology, Harvard Medical School (Dr Rifai), Boston, Mass; Franz-Volhard-Clinic, Charité, Humboldt-University, Berlin, Germany (Dr Pischon); and Department of Epidemiology, Merck Research Laboratories, West Point, Pa (Dr Girman).

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

High Molecular Weight Adiponectin Is Not Associated with Incident Coronary Heart Disease in Older Women: A Nested Prospective Case-Control Study
Sattar et al.
J. Clin. Endocrinol. Metab. 2008;93:1846-1849.
ABSTRACT | FULL TEXT  

Low Adiponectin Levels Are Associated With Atherogenic Dyslipidemia and Lipid-Rich Plaque in Nondiabetic Coronary Arteries
Marso et al.
Diabetes Care 2008;31:989-994.
ABSTRACT | FULL TEXT  

Adiponectin Protects Against Angiotensin II or Tumor Necrosis Factor {alpha}-Induced Endothelial Cell Monolayer Hyperpermeability: Role of cAMP/PKA Signaling
Xu et al.
Arterioscler. Thromb. Vasc. Bio. 2008;28:899-905.
ABSTRACT | FULL TEXT  

Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-{gamma}, and Proinflammatory Adipokines
Guo et al.
Circulation 2008;117:2253-2261.
ABSTRACT | FULL TEXT  

Cardiac Remodeling in Obesity
Abel et al.
Physiol. Rev. 2008;88:389-419.
ABSTRACT | FULL TEXT  

Prognostic Value of Adiponectin for Cardiovascular Disease and Mortality
Dekker et al.
J. Clin. Endocrinol. Metab. 2008;93:1489-1496.
ABSTRACT | FULL TEXT  

Adiponectin Antagonizes Stimulatory Effect of Tumor Necrosis Factor-{alpha} on Vascular Smooth Muscle Cell Calcification: Regulation of Growth Arrest-Specific Gene 6-Mediated Survival Pathway by Adenosine 5'-Monophosphate-Activated Protein Kinase
Son et al.
Endocrinology 2008;149:1646-1653.
ABSTRACT | FULL TEXT  

Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes Prevention Program
Mather et al.
Diabetes 2008;57:980-986.
ABSTRACT | FULL TEXT  

Plasma adiponectin levels and clinical outcomes among haemodialysis patients
Rao et al.
Nephrol Dial Transplant 2008;0:gfn070v1-gfn070.
ABSTRACT | FULL TEXT  

Peri-coronary epicardial adipose tissue is related to cardiovascular risk factors and coronary artery calcification in post-menopausal women
de Vos et al.
Eur Heart J 2008;29:777-783.
ABSTRACT | FULL TEXT  

Association of adiponectin with adverse outcome in coronary artery disease patients: results from the AtheroGene study
Schnabel et al.
Eur Heart J 2008;29:649-657.
ABSTRACT | FULL TEXT  

Implication of lipocalin-2 and visfatin levels in patients with coronary heart disease
Choi et al.
Eur J Endocrinol 2008;158:203-207.
ABSTRACT | FULL TEXT  

Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects
Patel et al.
Eur Heart J 2008;29:386-393.
ABSTRACT | FULL TEXT  

Is adiponectin and its genetic regulators useful or not for prediction of carotid intima-media thickness and coronary heart disease?
Nilsson
Eur Heart J 2008;29:293-295.
FULL TEXT  

Prevalence and Cluster of Cardiometabolic Biomarkers in Overweight and Obese Schoolchildren: Results from a Large Survey in Southwest Germany
Nagel et al.
Clin. Chem. 2008;54:317-325.
ABSTRACT | FULL TEXT  

Association of Adiponectin With Cerebrovascular Disease: A Nested Case-Control Study
Matsumoto et al.
Stroke 2008;39:323-328.
ABSTRACT | FULL TEXT  

Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction
Packard and Libby
Clin. Chem. 2008;54:24-38.
ABSTRACT | FULL TEXT  

Peripheral Inflammatory Biomarkers and Risk of Parkinson's Disease
Chen et al.
Am J Epidemiol 2008;167:90-95.
ABSTRACT | FULL TEXT  

Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity
Li et al.
Am. J. Physiol. Endocrinol. Metab. 2007;293:E1703-E1708.
ABSTRACT | FULL TEXT  

Statin reverses reduction of adiponectin receptor expression in infarcted heart and in TNF-{alpha}-treated cardiomyocytes in association with improved glucose uptake
Saito et al.
Am. J. Physiol. Heart Circ. Physiol. 2007;293:H3490-H3497.
ABSTRACT | FULL TEXT  

Coronary artery disease risk factors in patients with schizophrenia: effects of short term antipsychotic treatment
Sarandol et al.
J Psychopharmacol 2007;21:857-863.
ABSTRACT  

Inflamed Adipose Tissue: A Culprit Underlying the Metabolic Syndrome and Atherosclerosis
Gustafson et al.
Arterioscler. Thromb. Vasc. Bio. 2007;27:2276-2283.
ABSTRACT | FULL TEXT  

Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass
Kos et al.
Am. J. Physiol. Endocrinol. Metab. 2007;293:E1335-E1340.
ABSTRACT | FULL TEXT  

Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study
Galler et al.
Eur J Endocrinol 2007;157:481-489.
ABSTRACT | FULL TEXT  

Determinants of Serum Adiponectin in Persons with and without Type 1 Diabetes
Maahs et al.
Am J Epidemiol 2007;166:731-740.
ABSTRACT | FULL TEXT  

Increased Adiponectin Secretion by Highly Purified Eicosapentaenoic Acid in Rodent Models of Obesity and Human Obese Subjects
Itoh et al.
Arterioscler. Thromb. Vasc. Bio. 2007;27:1918-1925.
ABSTRACT | FULL TEXT  

Plasma Fluorescent Oxidation Products: Independent Predictors of Coronary Heart Disease in Men
Wu et al.
Am J Epidemiol 2007;166:544-551.
ABSTRACT | FULL TEXT  

Cardiovascular Actions of Insulin
Muniyappa et al.
Endocr. Rev. 2007;28:463-491.
ABSTRACT | FULL TEXT  

Determinants of Early Atherosclerosis in Obese Children and Adolescents
Beauloye et al.
J. Clin. Endocrinol. Metab. 2007;92:3025-3032.
ABSTRACT | FULL TEXT  

Circulating Adiponectin Levels and Mortality in Elderly Men With and Without Cardiovascular Disease and Heart Failure
Wannamethee et al.
Arch Intern Med 2007;167:1510-1517.
ABSTRACT | FULL TEXT  

Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure
Tsutamoto et al.
Eur Heart J 2007;28:1723-1730.
ABSTRACT | FULL TEXT  

Does adiponectin resistance exist in chronic heart failure?
Kintscher
Eur Heart J 2007;28:1676-1677.
FULL TEXT  

Associations of Adiponectin with Body Fat Distribution and Insulin Sensitivity in Nondiabetic Hispanics and African-Americans
Hanley et al.
J. Clin. Endocrinol. Metab. 2007;92:2665-2671.
ABSTRACT | FULL TEXT  

Adipokines and Coronary Vasomotor Dysfunction
Knudson et al.
Exp. Biol. Med. 2007;232:727-736.
ABSTRACT | FULL TEXT  

An Investigation of Hormone and Lipid Associations after Weight Loss in Women
Santosa et al.
J. Am. Coll. Nutr. 2007;26:250-258.
ABSTRACT | FULL TEXT  

Innate Immunity Modulates Adipokines in Humans
Anderson et al.
J. Clin. Endocrinol. Metab. 2007;92:2272-2279.
ABSTRACT | FULL TEXT  

Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment
Shibata et al.
Cardiovasc Res 2007;74:471-479.
ABSTRACT | FULL TEXT  

Hypoadiponectinemia as a Predictor for the Development of Hypertension: A 5-Year Prospective Study
Chow et al.
Hypertension 2007;49:1455-1461.
ABSTRACT | FULL TEXT  

Adiponectin levels in patients with intracranial atherosclerosis
Bang et al.
Neurology 2007;68:1931-1937.
ABSTRACT | FULL TEXT  

Biomarkers of Obesity and Subsequent Cardiovascular Events
Musaad and Haynes
Epidemiol Rev 2007;0:mxm005v1.
ABSTRACT | FULL TEXT  

Obesity, Inflammation, and Periodontal Disease
Pischon et al.
J. Dent. Res. 2007;86:400-409.
ABSTRACT | FULL TEXT  

Low-grade inflammation and hypoadiponectinaemia have an additive detrimental effect on aortic stiffness in essential hypertensive patients
Tsioufis et al.
Eur Heart J 2007;28:1162-1169.
ABSTRACT | FULL TEXT  

Low Dietary Sodium and Exogenous Angiotensin II Infusion Decrease Plasma Adiponectin Concentrations in Healthy Men
Lely et al.
J. Clin. Endocrinol. Metab. 2007;92:1821-1826.
ABSTRACT | FULL TEXT  

The Role of Endocannabinoid System Blockade in the Treatment of the Metabolic Syndrome
Kakafika et al.
J Clin Pharmacol 2007;47:642-652.
ABSTRACT | FULL TEXT  

Serum Adiponectin and Bone Mineral Density in Women
Richards et al.
J. Clin. Endocrinol. Metab. 2007;92:1517-1523.
ABSTRACT | FULL TEXT  

Adiponectin and cardiovascular disease: state of the art?
Szmitko et al.
Am. J. Physiol. Heart Circ. Physiol. 2007;292:H1655-H1663.
ABSTRACT | FULL TEXT  

Adiponectin actions in the cardiovascular system
Hopkins et al.
Cardiovasc Res 2007;74:11-18.
ABSTRACT | FULL TEXT  

Adiponectin Cardioprotection After Myocardial Ischemia/Reperfusion Involves the Reduction of Oxidative/Nitrative Stress
Tao et al.
Circulation 2007;115:1408-1416.
ABSTRACT | FULL TEXT  

Letter by Pischon et al Regarding Article, "Adiponectin and Coronary Heart Disease: A Prospective Study and Meta-Analysis"
Pischon et al.
Circulation 2007;115:e322-e322.
FULL TEXT  

Response to Letter Regarding Article, "Adiponectin and Coronary Heart Disease: A Prospective Study and Meta-Analysis"
Sattar et al.
Circulation 2007;115:e323-e323.
FULL TEXT  

Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism
Bjursell et al.
Diabetes 2007;56:583-593.
ABSTRACT | FULL TEXT  

Effects of Peroxisome Proliferator-Activated Receptor Ligands, Bezafibrate and Fenofibrate, on Adiponectin Level
Hiuge et al.
Arterioscler. Thromb. Vasc. Bio. 2007;27:635-641.
ABSTRACT | FULL TEXT  

Adiponectin and Cardiovascular Disease: Response to Therapeutic Interventions
Han et al.
J Am Coll Cardiol 2007;49:531-538.
ABSTRACT | FULL TEXT  

Association between plasma adiponectin levels and unstable coronary syndromes
Wolk et al.
Eur Heart J 2007;28:292-298.
ABSTRACT | FULL TEXT  

Adiponectin and risk of acute coronary syndromes: defining the obesity phenotype
Pischon and Rimm
Eur Heart J 2007;28:274-275.
FULL TEXT  

Serum Adiponectin and Renal Dysfunction in Men With Type 2 Diabetes
Lin et al.
Diabetes Care 2007;30:239-244.
ABSTRACT | FULL TEXT  

Sex Differences in Endothelial Function Markers Before Conversion to Pre-Diabetes: Does the Clock Start Ticking Earlier Among Women?: The Western New York Study
Donahue et al.
Diabetes Care 2007;30:354-359.
ABSTRACT | FULL TEXT  

Serum Adiponectin Is a Predictor of Coronary Heart Disease: A Population-Based 10-Year Follow-Up Study in Elderly Men
Frystyk et al.
J. Clin. Endocrinol. Metab. 2007;92:571-576.
ABSTRACT | FULL TEXT  

Redefining Risk in Acute Coronary Syndromes Using Molecular Medicine
Anwaruddin et al.
J Am Coll Cardiol 2007;49:279-289.
ABSTRACT | FULL TEXT  

Association of Adiponectin with Coronary Heart Disease and Mortality: The Rancho Bernardo Study
Laughlin et al.
Am J Epidemiol 2007;165:164-174.
ABSTRACT | FULL TEXT  

Adipose Tissue-Derived Factors: Impact on Health and Disease
Trujillo and Scherer
Endocr. Rev. 2006;27:762-778.
ABSTRACT | FULL TEXT  

Serum Adiponectin and Coronary Heart Disease Risk in Older Black and White Americans
Kanaya et al.
J. Clin. Endocrinol. Metab. 2006;91:5044-5050.
ABSTRACT | FULL TEXT  

Plasma Adiponectin Levels in Relation to Carotid Intima Media Thickness and Markers of Insulin Resistance
Nilsson et al.
Arterioscler. Thromb. Vasc. Bio. 2006;26:2758-2762.
ABSTRACT | FULL TEXT  

Transcardiac adiponectin gradient is independently related to endothelial vasomotor function in large and resistance coronary arteries in humans
Takano et al.
Am. J. Physiol. Heart Circ. Physiol. 2006;291:H2641-H2646.
ABSTRACT | FULL TEXT  

Insulin Resistance, Inflammatory Biomarkers, and Adipokines in Patients with Chronic Kidney Disease: Effects of Angiotensin II Blockade
de Vinuesa et al.
J. Am. Soc. Nephrol. 2006;17:S206-S212.
ABSTRACT | FULL TEXT  

Adiponectin and Mortality in Patients Undergoing Coronary Angiography
Pilz et al.
J. Clin. Endocrinol. Metab. 2006;91:4277-4286.
ABSTRACT | FULL TEXT  

Association of Adiponectin Gene Variations with Risk of Incident Myocardial Infarction and Ischemic Stroke: A Nested Case-Control Study
Hegener et al.
Clin. Chem. 2006;52:2021-2027.
ABSTRACT | FULL TEXT  

Inflammation and Atherothrombosis: From Population Biology and Bench Research to Clinical Practice
Libby and Ridker
J Am Coll Cardiol 2006;48:A33-A46.
ABSTRACT | FULL TEXT  

Serum Concentrations of Adiponectin and Risk of Type 2 Diabetes Mellitus and Coronary Heart Disease in Apparently Healthy Middle-Aged Men: Results From the 18-Year Follow-Up of a Large Cohort From Southern Germany
Koenig et al.
J Am Coll Cardiol 2006;48:1369-1377.
ABSTRACT | FULL TEXT  

Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain
Cavusoglu et al.
Eur Heart J 2006;27:2300-2309.
ABSTRACT | FULL TEXT  

Adiponectin and myocardial infarction: a paradox or a paradigm?
Teoh et al.
Eur Heart J 2006;27:2266-2268.
FULL TEXT  

Common Haplotypes at the Adiponectin Receptor 1 (ADIPOR1) Locus Are Associated With Increased Risk of Coronary Artery Disease in Type 2 Diabetes.
Soccio et al.
Diabetes 2006;55:2763-2770.
ABSTRACT | FULL TEXT  

The Relationships of Plasma Adiponectin with a Favorable Lipid Profile, Decreased Inflammation, and Less Ectopic Fat Accumulation Depend on Adiposity
Kantartzis et al.
Clin. Chem. 2006;52:1934-1942.
ABSTRACT | FULL TEXT  

A Big Fat Wedding: Association of Adiponectin With Coronary Vascular Lesions
Bajaj and Ben-Yehuda
J Am Coll Cardiol 2006;48:1163-1165.
FULL TEXT  

Plasma Adiponectin Levels Are Associated With Coronary Lesion Complexity in Men With Coronary Artery Disease
Otsuka et al.
J Am Coll Cardiol 2006;48:1155-1162.
ABSTRACT | FULL TEXT  

Is Plasma Oxidized Low-Density Lipoprotein, Measured With the Widely Used Antibody 4E6, an Independent Predictor of Coronary Heart Disease Among U.S. Men and Women?
Wu et al.
J Am Coll Cardiol 2006;48:973-979.
ABSTRACT | FULL TEXT  

Adiponectin and Mortality in Patients with Chronic Kidney Disease
Menon et al.
J. Am. Soc. Nephrol. 2006;17:2599-2606.
ABSTRACT | FULL TEXT  

The Effects of Diet on Inflammation: Emphasis on the Metabolic Syndrome
Giugliano et al.
J Am Coll Cardiol 2006;48:677-685.
ABSTRACT | FULL TEXT