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Risk Factors for Typhoid and Paratyphoid Fever in Jakarta, Indonesia
Albert M. Vollaard, MD;
Soegianto Ali, MD, MSc;
Henri A. G. H. van Asten, MD, MPH;
Suwandhi Widjaja, MD, PhD;
Leo G. Visser, MD, PhD;
Charles Surjadi, MD, PhD;
Jaap T. van Dissel, MD, PhD
JAMA. 2004;291:2607-2615.
Context The proportion of paratyphoid fever cases to typhoid fever cases may change due to urbanization and increased dependency on food purchased from street vendors. For containment of paratyphoid a different strategy may be needed than for typhoid, because risk factors for disease may not coincide and current typhoid vaccines do not protect against paratyphoid fever.
Objective To determine risk factors for typhoid and paratyphoid fever in an endemic area.
Design, Setting, and Participants Community-based case-control study conducted from June 2001 to February 2003 in hospitals and outpatient health centers in Jatinegara district, Jakarta, Indonesia. Enrolled participants were 1019 consecutive patients with fever lasting 3 or more days, from which 69 blood culture–confirmed typhoid cases, 24 confirmed paratyphoid cases, and 289 control patients with fever but without Salmonella bacteremia were interviewed, plus 378 randomly selected community controls.
Main Outcome Measures Blood culture–confirmed typhoid or paratyphoid fever; risk factors for both diseases.
Results In 1019 fever patients we identified 88 (9%) Salmonella typhi and 26 (3%) Salmonella paratyphi A infections. Paratyphoid fever among cases was independently associated with consumption of food from street vendors (comparison with community controls: odds ratio [OR], 3.34; 95% confidence interval [CI], 1.41-7.91; with fever controls: OR, 5.17; 95% CI, 2.12-12.60) and flooding (comparison with community controls: OR, 4.52; 95% CI, 1.90-10.73; with fever controls: OR, 3.25; 95% CI, 1.31-8.02). By contrast, independent risk factors for typhoid fever using the community control group were mostly related to the household, ie, to recent typhoid fever in the household (OR, 2.38; 95% CI, 1.03-5.48); no use of soap for handwashing (OR, 1.91; 95% CI, 1.06-3.46); sharing food from the same plate (OR, 1.93; 95% CI, 1.10-3.37), and no toilet in the household (OR, 2.20; 95% CI, 1.06-4.55). Also, typhoid fever was associated with young age in years (OR, 0.96; 95% CI, 0.94-0.98). In comparison with fever controls, risk factors for typhoid fever were use of ice cubes (OR, 2.27; 95% CI, 1.31-3.93) and female sex (OR, 1.79; 95% CI, 1.04-3.06). Fecal contamination of drinking water was not associated with typhoid or paratyphoid fever. We did not detect fecal carriers among food handlers in the households.
Conclusions In Jakarta, typhoid and paratyphoid fever are associated with distinct routes of transmission, with the risk factors for disease either mainly within the household (typhoid) or outside the household (paratyphoid).
Author Affiliations: Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands (Drs Vollaard, Visser, and van Dissel); Department of Biology, Medical Faculty (Dr Ali), Department of Internal Medicine (Dr Widjaja), and Center for Health Research (Dr Surjadi), Atma Jaya Catholic University, Jakarta, Indonesia; and Institute for International Health, University Medical Center Nijmegen, Nijmegen, the Netherlands (Dr van Asten).
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