 |
|
CLINICIAN'S CORNER
Modulating Angiogenesis
More vs Less
Branavan Sivakumar, MRCS (Eng);
Lorraine E. Harry, MRCS (Edin);
Ewa M. Paleolog, PhD
JAMA. 2004;292:972-977.
The concept of manipulation of the vascular bed to either increase or decrease the number of blood vessels has attracted considerable interest. This review focuses on angiogenesis as a therapeutic target, particularly in the context of cancer and arthritis, as well as on promoting angiogenesis in cardiovascular disease and the healing of bone fractures. Although once touted almost as a panacea for treatment of tumors, as well as other diseases associated with angiogenesis, such as diabetic retinopathy or rheumatoid arthritis, it is now clear that such enthusiasm was somewhat premature. Similarly, some clinical trials of therapeutic angiogenesis for the management of cardiovascular disease have been disappointing. Nevertheless, this exciting field of research holds promise for more targeted therapies.
Author Affiliations: Kennedy Institute of Rheumatology (Drs Sivakumar, Harry, and Paleolog) and Division of Surgery, Anaesthetics and Intensive Care Charing Cross Campus (Dr Paleolog), Faculty of Medicine, Imperial College, London; Mount Vernon Hospital, West Hertfordshire NHS Trust, Northwood (Dr Sivakumar), United Kingdom.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Tumor Recovery by Angiogenic Switch from Sprouting to Intussusceptive Angiogenesis after Treatment with PTK787/ZK222584 or Ionizing Radiation
Hlushchuk et al.
Am. J. Pathol. 2008;173:1173-1185.
ABSTRACT
| FULL TEXT
The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis
Pessler et al.
Ann Rheum Dis 2008;67:1184-1187.
ABSTRACT
| FULL TEXT
Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs
Lu et al.
Proc. Natl. Acad. Sci. USA 2007;104:12140-12145.
ABSTRACT
| FULL TEXT
Tomographic Fluorescence Imaging of Tumor Vascular Volume in Mice
Montet et al.
Radiology 2007;242:751-758.
ABSTRACT
| FULL TEXT
Fractalkine stimulates angiogenesis by activating the Raf-1/MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways
Lee et al.
Am. J. Physiol. Heart Circ. Physiol. 2006;291:H2836-H2846.
ABSTRACT
| FULL TEXT
Recruitment of a Prostaglandin E Receptor Subtype, EP3-Expressing Bone Marrow Cells Is Crucial in Wound-Induced Angiogenesis
Kamoshita et al.
Am. J. Pathol. 2006;169:1458-1472.
ABSTRACT
| FULL TEXT
Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction.
Conway et al.
Mol. Cell. Biol. 2006;26:5310-5324.
ABSTRACT
| FULL TEXT
Mechanisms of airway obliteration after lung transplantation.
Nicod
Proc Am Thorac Soc 2006;3:444-449.
ABSTRACT
| FULL TEXT
A Novel Protein Geranylgeranyltransferase-I Inhibitor with High Potency, Selectivity, and Cellular Activity
Peterson et al.
J. Biol. Chem. 2006;281:12445-12450.
ABSTRACT
| FULL TEXT
Upward weight percentile crossing in infancy and early childhood independently predicts fat mass in young adults: the Stockholm Weight Development Study (SWEDES)
Ekelund et al.
Am. J. Clin. Nutr. 2006;83:324-330.
ABSTRACT
| FULL TEXT
Custom Design of the Cardiac Microenvironment With Biomaterials
Davis et al.
Circ. Res. 2005;97:8-15.
ABSTRACT
| FULL TEXT
|
