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Nalini Singh, MD; David G. Armstrong, DPM, MSc, PhD; Benjamin A. Lipsky, MD

JAMA. 2005;293:217-228.

Context  Among persons diagnosed as having diabetes mellitus, the prevalence of foot ulcers is 4% to 10%, the annual population-based incidence is 1.0% to 4.1%, and the lifetime incidence may be as high as 25%. These ulcers frequently become infected, cause great morbidity, engender considerable financial costs, and are the usual first step to lower extremity amputation.

Objective  To systematically review the evidence on the efficacy of methods advocated for preventing diabetic foot ulcers in the primary care setting.

Data Sources, Study Selection, and Data Extraction  The EBSCO, MEDLINE, and the National Guideline Clearinghouse databases were searched for articles published between January 1980 and April 2004 using database-specific keywords. Bibliographies of retrieved articles were also searched, along with the Cochrane Library and relevant Web sites. We reviewed the retrieved literature for pertinent information, paying particular attention to prospective cohort studies and randomized clinical trials.

Data Synthesis  Prevention of diabetic foot ulcers begins with screening for loss of protective sensation, which is best accomplished in the primary care setting with a brief history and the Semmes-Weinstein monofilament. Specialist clinics may quantify neuropathy with biothesiometry, measure plantar foot pressure, and assess lower extremity vascular status with Doppler ultrasound and ankle-brachial blood pressure indices. These measurements, in conjunction with other findings from the history and physical examination, enable clinicians to stratify patients based on risk and to determine the type of intervention. Educating patients about proper foot care and periodic foot examinations are effective interventions to prevent ulceration. Other possibly effective clinical interventions include optimizing glycemic control, smoking cessation, intensive podiatric care, debridement of calluses, and certain types of prophylactic foot surgery. The value of various types of prescription footwear for ulcer prevention is not clear.

Conclusions  Substantial evidence supports screening all patients with diabetes to identify those at risk for foot ulceration. These patients might benefit from certain prophylactic interventions, including patient education, prescription footwear, intensive podiatric care, and evaluation for surgical interventions.

Author Affiliations: Department of Medicine, Divisions of Endocrinology and Metabolism (Dr Singh) and General Internal Medicine and Infectious Diseases (Dr Lipsky),Veterans Affairs Puget Sound Healthcare System and University of Washington School of Medicine, Seattle (Drs Singh and Lipsky); and Center for Lower Extremity Ambulatory Research, Dr William M. Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, Chicago, Ill (Dr Armstrong).

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