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Patterns of Care for Adults With Newly Diagnosed Malignant Glioma
Susan M. Chang, MD;
Ian F. Parney, MD, PhD;
Wei Huang, MS;
Frederick A. Anderson, Jr, PhD;
Anthony L. Asher, MD;
Mark Bernstein, MD;
Kevin O. Lillehei, MD;
Henry Brem, MD;
Mitchel S. Berger, MD;
Edward R. Laws, MD; for the Glioma Outcomes Project Investigators
JAMA. 2005;293:557-564.
Context Patients with malignant glioma (grade III or IV) face a poor prognosis, and few evidence-based treatment guidelines are available. There is a dearth of prospective data on patterns of care for these patients.
Objective To provide benchmark data to enable comparison of individual practice patterns and outcomes.
Design, Setting, and Patients The Glioma Outcomes (GO) Project enrolled 788 patients at 52 clinical sites, both academic and community practices, between December 1997 and July 2000. The enrollment criteria included adult patients with primary grade III or IV glioma undergoing a first or second operation for diagnosis or treatment. The data collection instruments included questionnaire forms given at enrollment, during the perioperative period, and at follow-up intervals of 3 months until death or a maximum of 24 months. Of the patients recorded in the GO database, 565 patients with newly diagnosed tumors were used for this analysis.
Main Outcome Measures Patterns of care (surgical management, perioperative care, postoperative management).
Results Most patients underwent magnetic resonance imaging (n = 518; 92%) and an attempt at tumor resection (n = 425; 75%). Cortical mapping (n = 107; 19%) and intraoperative image guidance (n = 161; 29%) were uncommon. Most received perioperative corticosteroids (n = 535; 99%) and antiepileptic medications (n = 497; 88%), but few received antidepressants (n = 38; 8%) or prophylactic heparin (n = 42; 7%). Most received adjuvant radiation therapy (n = 479; 87%), but fewer received chemotherapy (n = 300; 54%). Practice patterns varied significantly between academic and community settings.
Conclusions Reliance on magnetic resonance imaging, surgery, and radiation is generally accepted; however, relatively infrequent chemotherapy use may conflict with published literature, and frequent use of prophylactic antiepileptic medications contradicts established practice guidelines. Other practice patterns involving surgical adjuncts, prophylactic heparin, and antidepressants require further investigation to clarify appropriateness. Establishing further clinical guidelines may help reduce variability in practice patterns.
Author Affiliations: Department of Neurological Surgery, University of California, San Francisco (Drs Chang, Parney, and Berger); Center for Outcomes Research, Department of Surgery, University of Massachusetts Medical School, Worster (Ms Huang and Dr Anderson); Carolina Neurosurgery and Spine Associates, Charlotte, NC (Dr Asher); Division of Neurosurgery, University of Toronto, Toronto, Ontario (Dr Bernstein); Department of Neurological Surgery, University of Colorado, Denver (Dr Lillehei); Department of Neurological Surgery and Oncology, Johns Hopkins University, Baltimore, Md (Dr Brem); and Department of Neurological Surgery, University of Virginia, Charlottesville (Dr Laws).
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Patterns of Care for Adults With Malignant Glioma
Robert P. Shannon, Jerry W. Sayre, and Judith J. Sayre
JAMA. 2005;293(20):2469-2470.
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Patterns of Care for Adults With Malignant Glioma—Reply
Susan Chang, Ian F. Parney, Mitchel S. Berger, Frederick A. Anderson, Jr, Wei Huang, Anthony L. Asher, Mark Bernstein, Kevin O. Lillehei, Henry Brem, and Edward R. Laws
JAMA. 2005;293(20):2470.
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