This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (341)  • Contact me when this article is cited  Related Content  • Related letters  • Related article  • Similar articles in JAMA  Topic Collections  • Nutritional and Metabolic Disorders  • Lipids and Lipid Disorders  • Cardiovascular System  • Radiologic Imaging  • Ultrasonography  • Cardiovascular Disease/ Myocardial Infarction  • Alert me on articles by topic  Social Bookmarking   What's this?

The ASTEROID Trial

Steven E. Nissen, MD; Stephen J. Nicholls, MBBS, PhD; Ilke Sipahi, MD; Peter Libby, MD; Joel S. Raichlen, MD; Christie M. Ballantyne, MD; Jean Davignon, MD; Raimund Erbel, MD; Jean Charles Fruchart, PhD; Jean-Claude Tardif, MD; Paul Schoenhagen, MD; Tim Crowe, BS; Valerie Cain, MS; Kathy Wolski, MPH; Marlene Goormastic, MPH; E. Murat Tuzcu, MD; for the ASTEROID Investigators

JAMA. 2006;295:1556-1565. Published online March 13, 2006 (doi:10.1001/jama.295.13.jpc60002).

Context  Prior intravascular ultrasound (IVUS) trials have demonstrated slowing or halting of atherosclerosis progression with statin therapy but have not shown convincing evidence of regression using percent atheroma volume (PAV), the most rigorous IVUS measure of disease progression and regression.

Objective  To assess whether very intensive statin therapy could regress coronary atherosclerosis as determined by IVUS imaging.

Design and Setting  Prospective, open-label blinded end-points trial (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden [ASTEROID]) was performed at 53 community and tertiary care centers in the United States, Canada, Europe, and Australia. A motorized IVUS pullback was used to assess coronary atheroma burden at baseline and after 24 months of treatment. Each pair of baseline and follow-up IVUS assessments was analyzed in a blinded fashion.

Patients  Between November 2002 and October 2003, 507 patients had a baseline IVUS examination and received at least 1 dose of study drug. After 24 months, 349 patients had evaluable serial IVUS examinations.

Intervention  All patients received intensive statin therapy with rosuvastatin, 40 mg/d.

Main Outcome Measures  Two primary efficacy parameters were prespecified: the change in PAV and the change in nominal atheroma volume in the 10-mm subsegment with the greatest disease severity at baseline. A secondary efficacy variable, change in normalized total atheroma volume for the entire artery, was also prespecified.

Results  The mean (SD) baseline low-density lipoprotein cholesterol (LDL-C) level of 130.4 (34.3) mg/dL declined to 60.8 (20.0) mg/dL, a mean reduction of 53.2% (P<.001). Mean (SD) high-density lipoprotein cholesterol (HDL-C) level at baseline was 43.1 (11.1) mg/dL, increasing to 49.0 (12.6) mg/dL, an increase of 14.7% (P<.001). The mean (SD) change in PAV for the entire vessel was –0.98% (3.15%), with a median of –0.79% (97.5% CI, –1.21% to –0.53%) (P<.001 vs baseline). The mean (SD) change in atheroma volume in the most diseased 10-mm subsegment was –6.1 (10.1) mm³, with a median of –5.6 mm³ (97.5% CI, –6.8 to –4.0 mm³) (P<.001 vs baseline). Change in total atheroma volume showed a 6.8% median reduction; with a mean (SD) reduction of –14.7 (25.7) mm³, with a median of –12.5 mm³ (95% CI, –15.1 to –10.5 mm³) (P<.001 vs baseline). Adverse events were infrequent and similar to other statin trials.

Conclusions  Very high-intensity statin therapy using rosuvastatin 40 mg/d achieved an average LDL-C of 60.8 mg/dL and increased HDL-C by 14.7%, resulting in significant regression of atherosclerosis for all 3 prespecified IVUS measures of disease burden. Treatment to LDL-C levels below currently accepted guidelines, when accompanied by significant HDL-C increases, can regress atherosclerosis in coronary disease patients. Further studies are needed to determine the effect of the observed changes on clinical outcome.

Trial Registration  ClinicalTrials.gov Identifier: NCT00240318

Author Affiliations: Departments of Cardiovascular Medicine (Drs Nissen, Nicholls, Sipahi, Schoenhagen, and Tuzcu, Mr Crowe, and Mss Wolski and Goormastic) and Diagnostic Radiology (Dr Schoenhagen), Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio; Donald W. Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Mass (Dr Libby); AstraZeneca, Wilmington, Del (Dr Raichlen and Ms Cain); Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, Houston, Tex (Dr Ballantyne); Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec (Dr Davignon); Department of Cardiology, Universität Duisburg-Essen, Duisburg, Germany (Dr Erbel); Département de Recherche sur les Lipoproteines et l’Atherosclerose, Pasteur de Lille, Inserm U545 et Faculté de Pharmacie, Université du Droit et de la Santé de Lille 2, Lille, France (Dr Fruchart); and MHI Research Center, Montreal Heart Institute, Montreal, Quebec (Dr Tardif).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED LETTERS

High-Dose Statins and Atherosclerosis Regression
Sid C. Port
JAMA. 2006;296(15):1836.
EXTRACT | FULL TEXT  

High-Dose Statins and Atherosclerosis Regression
Yoseph Rozenman
JAMA. 2006;296(15):1836.
EXTRACT | FULL TEXT  

High-Dose Statins and Atherosclerosis Regression
Clemens von Birgelen and Marc Hartmann
JAMA. 2006;296(15):1837.
EXTRACT | FULL TEXT  

High-Dose Statins and Atherosclerosis Regression—Reply
Steven E. Nissen
JAMA. 2006;296(15):1837.
EXTRACT | FULL TEXT  

RELATED ARTICLE

Can a Potent Statin Actually Regress Coronary Atherosclerosis?
Roger S. Blumenthal and Navin K. Kapur
JAMA. 2006;295(13):1583-1584.
EXTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Efficacy of aggressive lipid controlling therapy for preventing saphenous vein graft disease.
Hata et al.
Ann. Thorac. Surg. 2009;88:1440-1444.
ABSTRACT | FULL TEXT  

Assessment of Coronary Plaque Progression in Coronary Computed Tomography Angiography Using a Semiquantitative Score
Lehman et al.
J Am Coll Cardiol Img 2009;2:1262-1270.
ABSTRACT | FULL TEXT  

Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors
Chapman et al.
Eur Heart J 2009;0:ehp399v1-ehp399.
ABSTRACT | FULL TEXT  

Statins in Acute Coronary Syndromes: Do the Guideline Recommendations Match the Evidence?
Morrissey et al.
J Am Coll Cardiol 2009;54:1425-1433.
ABSTRACT | FULL TEXT  

Advances in Intravascular Imaging
Maehara et al.
Circ Cardiovasc Interv 2009;2:482-490.
FULL TEXT  

High-density Lipoprotein Cholesterol: Current Perspective for Clinicians
Whayne
ANGIOLOGY 2009;60:644-649.
ABSTRACT  

ACCF/AHA/ACP 2009 competence and training statement: a curriculum on prevention of cardiovascular disease.
American College of Cardiology Foundation et al.
J Am Coll Cardiol 2009;54:1336-1363.
FULL TEXT  

ACCF/AHA/ACP 2009 Competence and Training Statement: A Curriculum on Prevention of Cardiovascular Disease: A Report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Competence and Training (Writing Committee to Develop a Competence and Training Statement on Prevention of Cardiovascular Disease): Developed in Collaboration With the American Academy of Neurology; American Association of Cardiovascular and Pulmonary Rehabilitation; American College of Preventive Medicine; American College of Sports Medicine; American Diabetes Association; American Society of Hypertension; Association of Black Cardiologists; Centers for Disease Control and Prevention; National Heart, Lung, and Blood Institute; National Lipid Association; and Preventive Cardiovascular Nurses Association
WRITING COMMITTEE MEMBERS et al.
Circulation 2009;120:e100-e126.
FULL TEXT  

Primary and Secondary Prevention of Cardiovascular Diseases: A Practical Evidence-Based Approach
O'Keefe et al.
Mayo Clin Proc. 2009;84:741-757.
ABSTRACT | FULL TEXT  

Angiotensin-converting enzyme inhibitors and atherosclerotic plaque: a key role in the cardiovascular protection of patients with coronary artery disease
Tardif
Eur Heart J Suppl 2009;11:E9-E16.
ABSTRACT | FULL TEXT  

Effect of intensive statin therapy on regression of coronary atherosclerosis in patients with acute coronary syndrome: a multicenter randomized trial evaluated by volumetric intravascular ultrasound using pitavastatin versus atorvastatin (JAPAN-ACS [Japan assessment of pitavastatin and atorvastatin in acute coronary syndrome] study).
Hiro et al.
J Am Coll Cardiol 2009;54:293-302.
ABSTRACT | FULL TEXT  

Structural and functional manifestations of human atherosclerosis: do they run in parallel?
Ganz et al.
Eur Heart J 2009;30:1556-1558.
FULL TEXT  

Attenuated Plaque at Nonculprit Lesions in Patients Enrolled in Intravascular Ultrasound Atherosclerosis Progression Trials
Bayturan et al.
J Am Coll Cardiol Intv 2009;2:672-678.
ABSTRACT | FULL TEXT  

Effects of Statin Treatments on Coronary Plaques Assessed by Volumetric Virtual Histology Intravascular Ultrasound Analysis
Hong et al.
J Am Coll Cardiol Intv 2009;2:679-688.
ABSTRACT | FULL TEXT  

Effect of Fluvastatin on Progression of Coronary Atherosclerotic Plaque Evaluated by Virtual Histology Intravascular Ultrasound
Nasu et al.
J Am Coll Cardiol Intv 2009;2:689-696.
ABSTRACT | FULL TEXT  

Can Statins Alter Coronary Plaque Composition Assessed by Radiofrequency Backscatter Intravascular Ultrasound?
Samady and McDaniel
J Am Coll Cardiol Intv 2009;2:697-700.
FULL TEXT  

The Vytorin on Carotid Intima-Media Thickness and Overall Arterial Rigidity (VYCTOR) Study
Meaney et al.
J Clin Pharmacol 2009;49:838-847.
ABSTRACT | FULL TEXT  

The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study: Evaluation Using Ultrasmall Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging in Carotid Disease
Tang et al.
J Am Coll Cardiol 2009;53:2039-2050.
ABSTRACT | FULL TEXT  

Rosuvastatin 20 mg restores normal HDL-apoA-I kinetics in type 2 diabetes
Verges et al.
J. Lipid Res. 2009;50:1209-1215.
ABSTRACT | FULL TEXT  

Disease progression in nonintervened saphenous vein graft segments a serial intravascular ultrasound analysis.
Hong et al.
J Am Coll Cardiol 2009;53:1257-1264.
ABSTRACT | FULL TEXT  

Low levels of low-density lipoprotein cholesterol and blood pressure and progression of coronary atherosclerosis.
Chhatriwalla et al.
J Am Coll Cardiol 2009;53:1110-1115.
ABSTRACT | FULL TEXT  

Atheroma volume by intravascular ultrasound as a surrogate for clinical end points.
Tobis and Perlowski
J Am Coll Cardiol 2009;53:1116-1118.
FULL TEXT  

Loss of small heterodimer partner expression in the liver protects against dyslipidemia
Hartman et al.
J. Lipid Res. 2009;50:193-203.
ABSTRACT | FULL TEXT  

Response to Letter of Mascitelli L, Ravnskov U, Pezzetta F, and Goldstein M
Whayne
ANGIOLOGY 2009;60:129-130.
 

JUPITER to Earth: A statin helps people with normal LDL-C and high hs-CRP, but what does it mean?
SHISHEHBOR and HAZEN
Cleveland Clinic Journal of Medicine 2009;76:37-44.
ABSTRACT | FULL TEXT  

The Effect of Atorvastatin in Patients with Polycystic Ovary Syndrome: A Randomized Double-Blind Placebo-Controlled Study
Sathyapalan et al.
J. Clin. Endocrinol. Metab. 2009;94:103-108.
ABSTRACT | FULL TEXT  

Cholesteryl Ester Transfer Protein Inhibition, High-Density Lipoprotein Raising, and Progression of Coronary Atherosclerosis: Insights From ILLUSTRATE (Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosclerosis by CETP Inhibition and HDL Elevation)
Nicholls et al.
Circulation 2008;118:2506-2514.
ABSTRACT | FULL TEXT  

Treatment of Chronic Obstructive Pulmonary Disease and Its Comorbidities
Luppi et al.
Proc Am Thorac Soc 2008;5:848-856.
ABSTRACT | FULL TEXT  

Statins: established indications and controversial subgroups
Jukema and Bergheanu
Heart 2008;94:1656-1662.
FULL TEXT  

Letter by Kaneda Regarding Article, "Effect of Rosuvastatin Therapy on Coronary Artery Stenoses Assessed by Quantitative Coronary Angiography: A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden"
Kaneda
Circulation 2008;118:e706-e706.
FULL TEXT  

Letter by Sutton et al Regarding Article, "Effect of Rosuvastatin Therapy on Coronary Artery Stenoses Assessed by Quantitative Coronary Angiography: A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden"
Sutton et al.
Circulation 2008;118:e707-e707.
FULL TEXT  

Response to Letters Regarding Article, "Effect of Rosuvastatin Therapy on Coronary Artery Stenoses Assessed by Quantitative Coronary Angiography: A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden"
Ballantyne et al.
Circulation 2008;118:e708-e708.
FULL TEXT  

Is Carotid Intima-Media Thickness a Reliable Clinical Predictor?-Reply-I
O'Keefe et al.
Mayo Clin Proc. 2008;83:1300-1301.
FULL TEXT  

Targeting residual cardiovascular risk: raising high-density lipoprotein cholesterol levels
Hausenloy and Yellon
Postgrad. Med. J. 2008;84:590-598.
ABSTRACT | FULL TEXT  

Effects of rosuvastatin on cardiovascular morphology and function in an ApoE-knockout mouse model of atherosclerosis
Gronros et al.
Am. J. Physiol. Heart Circ. Physiol. 2008;295:H2046-H2053.
ABSTRACT | FULL TEXT  

Effects of the Direct Lipoprotein-Associated Phospholipase A2 Inhibitor Darapladib on Human Coronary Atherosclerotic Plaque
Serruys et al.
Circulation 2008;118:1172-1182.
ABSTRACT | FULL TEXT  

An Overview of the Extra-Lipid Effects of Rosuvastatin
Kostapanos et al.
J CARDIOVASC PHARMACOL THER 2008;13:157-174.
ABSTRACT  

Pioglitazone vs Glimepiride in the PERISCOPE Trial
Fresco
JAMA 2008;300:787-787.
FULL TEXT  

Unraveling Pleiotropic Effects Of Statins: Bit By Bit, a Slow Case With Perspective
Arslan et al.
Circ. Res. 2008;103:334-336.
FULL TEXT  

Dose-Dependent Effect of Rosuvastatin on VLDL-Apolipoprotein C-III Kinetics in the Metabolic Syndrome
Ooi et al.
Diabetes Care 2008;31:1656-1661.
ABSTRACT | FULL TEXT  

Intensive Lipid Intervention in the Post-ENHANCE Era
O'Keefe et al.
Mayo Clin Proc. 2008;83:867-869.
FULL TEXT  

Rosuvastatin and Cardiovascular Disease: Did the Strongest Statin Hold the Initial Promises?
Efthimiadis
ANGIOLOGY 2008;59:62S-64S.
ABSTRACT  

Effect of Diabetes on Progression of Coronary Atherosclerosis and Arterial Remodeling: A Pooled Analysis of 5 Intravascular Ultrasound Trials
Nicholls et al.
J Am Coll Cardiol 2008;52:255-262.
ABSTRACT | FULL TEXT  

Relationship Between Biomarkers of Oxidized Low-Density Lipoprotein, Statin Therapy, Quantitative Coronary Angiography, and Atheroma Volume Observations From the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) Study.
Choi et al.
J Am Coll Cardiol 2008;52:24-32.
ABSTRACT | FULL TEXT  

Is ezetimibe/simvastatin no better than simvastatin alone? Lessons learned and clinical implications
DAVIDSON
Cleveland Clinic Journal of Medicine 2008;75:479-496.
FULL TEXT  

Targeting residual cardiovascular risk: raising high-density lipoprotein cholesterol levels
Hausenloy and Yellon
Heart 2008;94:706-714.
ABSTRACT | FULL TEXT  

Effect of Rosuvastatin Therapy on Coronary Artery Stenoses Assessed by Quantitative Coronary Angiography: A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden
Ballantyne et al.
Circulation 2008;117:2458-2466.
ABSTRACT | FULL TEXT  

Vascular effects of diets, especially plant sterol ester consumption.
Miettinen and Gylling
J Am Coll Cardiol 2008;51:1562-1563.
FULL TEXT  

Comparison of Pioglitazone vs Glimepiride on Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes: The PERISCOPE Randomized Controlled Trial
Nissen et al.
JAMA 2008;299:1561-1573.
ABSTRACT | FULL TEXT  

Effect of Rimonabant on Progression of Atherosclerosis in Patients With Abdominal Obesity and Coronary Artery Disease: The STRADIVARIUS Randomized Controlled Trial
Nissen et al.
JAMA 2008;299:1547-1560.
ABSTRACT | FULL TEXT  

Ultrasound imaging techniques for the evaluation of cardiovascular therapies
Kastelein and de Groot
Eur Heart J 2008;29:849-858.
ABSTRACT | FULL TEXT  

Rapid change in plaque size, composition, and molecular footprint after recombinant apolipoprotein A-I Milano (ETC-216) administration: magnetic resonance imaging study in an experimental model of atherosclerosis.
Ibanez et al.
J Am Coll Cardiol 2008;51:1104-1109.
ABSTRACT | FULL TEXT  

Applications of statins in cardiothoracic surgery: more than just lipid-lowering
Paraskevas
Eur. J. Cardiothorac. Surg. 2008;33:377-390.
ABSTRACT | FULL TEXT  

Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice
Glaros et al.
J. Lipid Res. 2008;49:324-331.
ABSTRACT | FULL TEXT  

Dose-Dependent Regulation of High-Density Lipoprotein Metabolism with Rosuvastatin in the Metabolic Syndrome
Ooi et al.
J. Clin. Endocrinol. Metab. 2008;93:430-437.
ABSTRACT | FULL TEXT  

Lipid Management to Reduce Cardiovascular Risk: A New Strategy Is Required
Superko and King
Circulation 2008;117:560-568.
FULL TEXT  

Clinical Relevance of Non-HDL Cholesterol in Patients With Diabetes
Peters
Clin. Diabetes 2008;26:3-7.
ABSTRACT | FULL TEXT  

Sex-Dependent Attenuation of Plaque Growth After Treatment With Bone Marrow Mononuclear Cells
Nelson et al.
Circ. Res. 2007;101:1319-1327.
ABSTRACT | FULL TEXT  

Resolution of Asymptomatic Myocardial Ischemia in Patients With Type 2 Diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study
Wackers et al.
Diabetes Care 2007;30:2892-2898.
ABSTRACT | FULL TEXT  

Beyond Low-Density Lipoprotein Cholesterol: Defining the Role of Low-Density Lipoprotein Heterogeneity in Coronary Artery Disease
Mudd et al.
J Am Coll Cardiol 2007;50:1735-1741.
ABSTRACT | FULL TEXT  

Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery
Feringa et al.
J Am Coll Cardiol 2007;50:1649-1656.
ABSTRACT | FULL TEXT  

Long-Term Follow-up of the West of Scotland Coronary Prevention Study
Ford et al.
NEJM 2007;357:1477-1486.
ABSTRACT | FULL TEXT  

European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by representatives of nine societies and by invited experts)
Authors/Task Force Members et al.
Eur Heart J 2007;28:2375-2414.
FULL TEXT  

Assessment of Culprit Lesion Morphology in Acute Myocardial Infarction: Ability of Optical Coherence Tomography Compared With Intravascular Ultrasound and Coronary Angioscopy
Kubo et al.
J Am Coll Cardiol 2007;50:933-939.
ABSTRACT | FULL TEXT  

Review: Statin plus thiazolidinedione use in patients with diabetes at high cardiovascular risk
Erdmann
British Journal of Diabetes & Vascular Disease 2007;7:211-216.
ABSTRACT  

Should Statins Be Given Routinely Before Carotid Endarterectomy?
Perler
PERSPECT VASC SURG ENDOVASC THER 2007;19:240-245.
ABSTRACT  

ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine
Anderson et al.
J Am Coll Cardiol 2007;50:e1-e157.
FULL TEXT  

Intensive statin therapy in acute coronary syndromes and stable coronary heart disease: a comparative meta-analysis of randomised controlled trials
Afilalo et al.
Heart 2007;93:914-921.
ABSTRACT | FULL TEXT  

Atorvastatin Treatment and Vaccination Efficacy
Packard et al.
J Clin Pharmacol 2007;47:1022-1027.
FULL TEXT  

{beta}-Blockers and Progression of Coronary Atherosclerosis: Pooled Analysis of 4 Intravascular Ultrasonography Trials
Sipahi et al.
ANN INTERN MED 2007;147:10-18.
ABSTRACT | FULL TEXT  

Review: Imaging to assess effect of medical therapy in patients with diabetes mellitus
Raggi and Bellasi
British Journal of Diabetes & Vascular Disease 2007;7:157-164.
ABSTRACT  

Do statins have an antiarrhythmic activity?
Kostapanos et al.
Cardiovasc Res 2007;75:10-20.
ABSTRACT | FULL TEXT  

Response to anti-tumour necrosis factor alpha blockade is associated with reduction of carotid intima-media thickness in patients with active rheumatoid arthritis
Del Porto et al.
Rheumatology (Oxford) 2007;46:1111-1115.
ABSTRACT | FULL TEXT  

The significance of low HDL-cholesterol levels in an ageing society at increased risk for cardiovascular disease
Windler et al.
Diabetes and Vascular Disease Research 2007;4:136-142.
ABSTRACT  

Do Statins Lower Blood Pressure?
Mangat et al.
J CARDIOVASC PHARMACOL THER 2007;12:112-123.
ABSTRACT  

Intravascular ultrasound radiofrequency analysis of coronary atherosclerosis: an emerging technology for the assessment of vulnerable plaque
Mehta et al.
Eur Heart J 2007;28:1283-1288.
ABSTRACT | FULL TEXT  

Type 2 diabetes patients: profiles, treatment and daily practice
Zambon
Diabetes and Vascular Disease Research 2007;4:S12-S16.
 

Lower Progression Rate of End-Stage Renal Disease in Patients with Peripheral Arterial Disease Using Statins or Angiotensin-Converting Enzyme Inhibitors
Feringa et al.
J. Am. Soc. Nephrol. 2007;18:1872-1879.
ABSTRACT | FULL TEXT  

Local Production of Lipoprotein-Associated Phospholipase A2 and Lysophosphatidylcholine in the Coronary Circulation: Association With Early Coronary Atherosclerosis and Endothelial Dysfunction in Humans
Lavi et al.
Circulation 2007;115:2715-2721.
ABSTRACT | FULL TEXT  

Recurrent angina after coronary revascularization: a clinical challenge
Abbate et al.
Eur Heart J 2007;28:1057-1065.
ABSTRACT | FULL TEXT  

Safety of Aggressive Lipid Management
Davidson and Robinson
J Am Coll Cardiol 2007;49:1753-1762.
ABSTRACT | FULL TEXT  

Achieving Low-Density Lipoprotein Cholesterol Goals in High-Risk Patients in Managed Care: Comparison of Rosuvastatin, Atorvastatin, and Simvastatin in the SOLAR Trial
Insull et al.
Mayo Clin Proc. 2007;82:543-550.
ABSTRACT | FULL TEXT  

The Year in Atherothrombosis
Sanz et al.
J Am Coll Cardiol 2007;49:1740-1749.
FULL TEXT  

Effects of Reconstituted High-Density Lipoprotein Infusions on Coronary Atherosclerosis: A Randomized Controlled Trial
Tardif et al.
JAMA 2007;297:1675-1682.
ABSTRACT | FULL TEXT