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Prevalence of Pathogenic BRCA1 Mutation Carriers in 5 US Racial/Ethnic Groups
Esther M. John, PhD;
Alexander Miron, PhD;
Gail Gong, PhD;
Amanda I. Phipps, MPH;
Anna Felberg, MS;
Frederick P. Li, MD;
Dee W. West, PhD;
Alice S. Whittemore, PhD
JAMA. 2007;298(24):2869-2876.
Context Information on the prevalence of pathogenic BRCA1 mutation carriers in racial/ethnic minority populations is limited.
Objective To estimate BRCA1 carrier prevalence in Hispanic, African American, and Asian American female breast cancer patients compared with non-Hispanic white patients with and without Ashkenazi Jewish ancestry.
Design, Setting, and Participants We estimated race/ethnicity-specific prevalence of BRCA1 in a population-based, multiethnic series of female breast cancer patients younger than 65 years at diagnosis who were enrolled at the Northern California site of the Breast Cancer Family Registry during the period 1996-2005. Race/ethnicity and religious ancestry were based on self-report. Weighted estimates of prevalence and 95% confidence intervals (CIs) were based on Horvitz-Thompson estimating equations.
Main Outcome Measure Estimates of BRCA1 prevalence.
Results Estimates of BRCA1 prevalence were 3.5% (95% CI, 2.1%-5.8%) in Hispanic patients (n = 393), 1.3% (95% CI, 0.6%-2.6%) in African American patients (n = 341), and 0.5% (95% CI, 0.1%-2.0%) in Asian American patients (n = 444), compared with 8.3% (95% CI, 3.1%-20.1%) in Ashkenazi Jewish patients (n = 41) and 2.2% (95% CI, 0.7%-6.9%) in other non-Hispanic white patients (n = 508). Prevalence was particularly high in young (<35 years) African American patients (5/30 patients [16.7%]; 95% CI, 7.1%-34.3%). 185delAG was the most common mutation in Hispanics, found in 5 of 21 carriers (24%).
Conclusions Among African American, Asian American, and Hispanic patients in the Northern California Breast Cancer Family Registry, the prevalence of BRCA1 mutation carriers was highest in Hispanics and lowest in Asian Americans. The higher carrier prevalence in Hispanics may reflect the presence of unrecognized Jewish ancestry in this population.
Author Affiliations: Northern California Cancer Center, Fremont (Drs John and West and Ms Phipps); Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California (Drs John, Gong, West, and Whittemore and Ms Felberg); and Dana-Farber Cancer Institute, Boston, Massachusetts (Drs Miron and Li).
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