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Cost-effectiveness of Bone Densitometry Followed by Treatment of Osteoporosis in Older Men
John T. Schousboe, MD, MS;
Brent C. Taylor, PhD, MPH;
Howard A. Fink, MD, MPH;
Robert L. Kane, MD;
Steven R. Cummings, MD;
Eric S. Orwoll, MD;
L. Joseph Melton III, MD, MPH;
Douglas C. Bauer, MD;
Kristine E. Ensrud, MD, MPH
JAMA. 2007;298:629-637.
Context Osteoporotic fractures are common among elderly men.
Objective To evaluate among older men the cost-effectiveness of bone densitometry followed by 5 years of oral bisphosphonate therapy to prevent fractures for those found to have osteoporosis (femoral neck T score  –2.5), compared with no intervention.
Design, Setting, and Population Computer Markov microsimulation model using a societal perspective and a lifetime horizon. Simulations were performed for hypothetical cohorts of white men aged 65, 70, 75, 80, or 85 years, with or without prior clinical fracture. Data sources for model parameters included the Rochester Epidemiology Project for fracture costs and population-based age-specific fracture rates; the Osteoporotic Fractures in Men (MrOS) study and published meta-analyses for the associations among prior fractures, bone density, and incident fractures; and published studies of fracture disutility.
Main Outcome Measures Costs per quality-adjusted life-year (QALY) gained for the densitometry and follow-up treatment strategy compared with no intervention, calculated from lifetime costs and accumulated QALYs for each strategy.
Results Lifetime costs per QALY gained for the densitometry and follow-up treatment strategy were less than $50 000 for men aged 65 years or older with a prior clinical fracture and for men aged 80 years or older without a prior fracture. These results were most sensitive to oral bisphosphonate cost and fracture reduction efficacy, the strength of association between bone mineral density and fractures, fracture rates and disutility, and medication adherence.
Conclusions Bone densitometry followed by bisphosphonate therapy for those with osteoporosis may be cost-effective for men aged 65 years or older with a self-reported prior clinical fracture and for men aged 80 to 85 years with no prior fracture. This strategy may also be cost-effective for men as young as 70 years without a prior clinical fracture if oral bisphosphonate costs are less than $500 per year or if the societal willingness to pay per QALY gained is $100 000.
Author Affiliations: Park Nicollet Health Services (Dr Schousboe), Divisions of Health Policy and Management (Drs Schousboe and Kane) and Epidemiology (Drs Fink and Ensrud), School of Public Health, and Clinical Outcomes Research Center (Dr Kane), University of Minnesota, Center for Chronic Disease Outcomes Research (Drs Taylor, Fink, and Ensrud) and Geriatric Research Education and Clinical Center (Dr Fink), Veterans Affairs Medical Center, Department of Medicine, Veterans Administration Medical Center (Drs Fink and Ensrud), Minneapolis, Minnesota; San Francisco Coordinating Center, California Pacific Medical Center Research Institute (Dr Cummings), and Department of Medicine and Epidemiology, University of California at San Francisco (Dr Bauer), San Francisco; Department of Medicine, Oregon Health Sciences University, Portland (Dr Orwoll); and Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota (Dr Melton).
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