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APOE Polymorphisms and Late-Onset Alzheimer Disease
The Importance of Ethnicity
Walter A. Kukull, PhD;
George M. Martin, MD
JAMA. 1998;279:788-789.
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Ethnic groups traditionally have been underrepresented in research, and research in diseases of aging is no exception. To increase recruitment of underrepresented ethnic groups, the National Institute on Aging has provided supplementary funds to Alzheimer disease (AD) centers around the country for the purpose of recruiting cohorts of patients and controls. In this issue of THE JOURNAL, we see an example of the fruits of such research with these patient populations. Tang and colleagues,1 who have helped pioneer the development of epidemiologic research on late-life dementias, report that African Americans and Hispanics living in Manhattan have a higher relative risk of possible or probable AD than whites. Unlike their white neighbors, however, there is little evidence that their risk of developing this devastating disorder is enhanced by carrying 1 of 3 relatively common variants of the gene that codes for apolipoprotein E . . . [Full Text of this Article]
From the Departments of Epidemiology (Dr Kukull), Pathology (Dr Martin), and Genetics (Dr Martin) and the Alzheimer's Disease Research Center (Drs Kukull and Martin), University of Washington, Seattle.
RELATED ARTICLE
The APOE- 4 Allele and the Risk of Alzheimer Disease Among African Americans, Whites, and Hispanics
Ming-Xin Tang, Yaakov Stern, Karen Marder, Karen Bell, Barry Gurland, Rafael Lantigua, Howard Andrews, Lin Feng, Benjamin Tycko, and Richard Mayeux
JAMA. 1998;279(10):751-755.
ABSTRACT
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
The APOE-{epsilon}4 Allele and Alzheimer Disease Among African Americans, Hispanics, and Whites
Barker et al.
JAMA 1998;280:1661-1663.
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