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Fergus J. Couch, PhD; Lynn C. Hartmann, MD

JAMA. 1998;279:955-957.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Since the original localization¹ and cloning² of BRCA1, a key question has been: What proportion of the overall burden of breast cancer is attributable to mutations in this susceptibility gene? Previous studies have focused on 4 categories of individuals: members of high-risk families (those with apparent single-gene, autosomal dominant transmission of susceptibility to breast and/or ovarian cancer); genetically distinctive populations such as persons of Ashkenazi extraction; women with early-onset breast cancer; and women seen in high-risk breast cancer clinics (from moderate- and high-risk families). Findings from select published reports in these groups and highlights of findings of 2 articles in this issue of JAMA are summarized in Table 1. ^3-18

Table appears in full text version. Germline BRCA1 Mutations in Select Populations

The first studies of BRCA1 mutation prevalence suggested that nearly half of the families at high risk for breast cancer carried BRCA1 mutations.^19-20 In the . . . [Full Text of this Article]

From the Departments of Laboratory Medicine and Pathology and Oncology, Mayo Clinic and Foundation, Rochester, Minn.

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