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To the Editor.—The Bogalusa Heart Study¹ recently provided new evidence linking serum lipid concentrations and obesity in children and young adults with a family history of coronary heart disease (CHD). Prevention of CHD, a major health problem in the developed world, may be based on a decrease of exposure to the known risk factors in the population or on selective search for high-risk individuals and more aggressive manipulation of their risk factors. As suggested by the Editorial,² interventions beginning in early childhood are probably effective, safe, and feasible.

The children in the Bogalusa Heart Study were followed up from the age of 10 years to 26 years. Permanent decreases in serum low-density lipoprotein cholesterol concentrations in early life are likely to delay the progression of atherosclerosis. It might be feasible to intervene early and expand CHD prevention to all children, without any cholesterol testing. This has been done in . . . [Full Text of this Article]

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