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Charles Marwick

JAMA. 1998;279:1425.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE ETHICAL ISSUES involved in protecting human subjects who participate in medical research in countries outside the United States will be reviewed by the National Bioethics Advisory Commission. The group's decision reflects growing concern about the conduct of medical research on human subjects in other nations, especially in so-called developing countries. The topic has been the subject of contentious debate.

At a meeting of the commission last July, Sidney M. Wolfe, MD, director of the Health Research Group, Washington, DC, drew attention to what he termed "unethical studies" in several countries involving the investigation of zidovudine (also known as AZT) in controlling fetal transmission of the human immunodeficiency virus (HIV). Despite evidence that treatment with zidovudine effectively reduced mother-to-infant transmission, placebo groups did not receive the drug. These studies, said Wolfe, denied women access to known effective treatment and would have been unethical if done in the United . . . [Full Text of this Article]

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