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David Moher, MSc

JAMA. 1998;279:1489-1491.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

REPORTS OF RANDOMIZED controlled trials (RCTs) have become the "gold standard" by which health care professionals make decisions about the effectiveness of most interventions. Such reports, accurately documenting the conduct of RCTs, should be of the highest possible quality to ensure that their results are as free of bias as possible. Proposals to help improve the quality of reports of RCTs have existed for some time.^1-2 Unfortunately, the evidence indicates that there is still considerable room for improvement in how RCTs are reported.

Pocock and colleagues³ reported that a statement about sample size was mentioned in only 5 (11.1%) of 45 reports and that only 6 (13.3%) made use of confidence intervals. These investigators also noted that the statistical analysis tended to exaggerate intervention efficacy because authors reported a higher proportion of statistically significant results in their abstracts compared with the body of the papers. Altman and . . . [Full Text of this Article]

From the Departments of Pediatrics, Medicine, and Epidemiology and Community Medicine, Children's Hospital of Eastern Ontario Research Institute, University of Ottawa.

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