 |
|
SV40-Contaminated Poliovirus Vaccine and Childhood Cancer Risk
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
To the Editor.—In examining the carcinogenic effects of exposure to simian virus 40 (SV40)–contaminated poliovirus vaccine, Strickler et al1 concluded that such exposure "was not associated with significantly increased rates of ependymomas and other brain cancers, osteosarcomas, or mesotheliomas." The expectation that the available data provided reliable incidence rates for a comparative analysis using Poisson regression techniques deserves reconsideration.
The Surveillance, Epidemiology, and End Results (SEER) database captures only tumors occurring during ages 26 to 41 years, 17 to 31 years, and 9 to 24 years in the childhood-exposed, infant-exposed, and unexposed cohorts, respectively, as defined by Strickler et al. Clearly, the ages for which tumor incidence is known for the entire childhood-exposed and unexposed cohort are incongruent. Poisson regression is a powerful statistical tool; however, negative conclusions drawn from a comparison of 2 or more regression models mathematically generated from incidence rates of very different age groups may . . . [Full Text of this Article]
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED ARTICLE
Contamination of Poliovirus Vaccines With Simian Virus 40 (1955-1963) and Subsequent Cancer Rates
Howard D. Strickler, Philip S. Rosenberg, Susan S. Devesa, Joan Hertel, Joseph F. Fraumeni, Jr, and James J. Goedert
JAMA. 1998;279(4):292-295.
ABSTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Cell and Molecular Biology of Simian Virus 40: Implications for Human Infections and Disease
Butel and Lednicky
JNCI J Natl Cancer Inst 1999;91:119a-134a.
ABSTRACT
| FULL TEXT
|
