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To the Editor.—Toxic epidermal necrolysis (TEN) is a serious, usually drug-induced, dermatosis characterized by extensive erythema, necrosis, bullous detachment of the epidermis, constitutional symptoms, and visceral involvement.^1-4 We report a case of TEN apparently caused by atorvastatin, an antihyperlipidemic drug in the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor class. We are unaware of any published reports of TEN associated with atorvastatin or related compounds.⁵

Report of a Case

A 73-year-old, moderately obese woman with type 2 diabetes and hypertension had a total cholesterol value of 6.88 mmol/L (266 mg/dL), a high-density lipoprotein cholesterol value of 1.03 mmol/L (40 mg/dL), a low-density lipoprotein cholesterol value of 4.58 mmol/L (177 mg/dL), and a triglyceride value of 6.88 mmol/L (266 mg/dL). She had been receiving the following medications without adverse effects: enalapril and glyburide, 6 years; potassium chloride, 14 years; hydrochlorothiazide, 15 months; and metformin and nabumetone, 1 year. Atorvastatin, 10 mg/d, was prescribed.

Four days . . . [Full Text of this Article]

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