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To the Editor.— In their article, Dr Misrahi and colleagues¹ try to correlate a CCR5 gene polymorphism with resistance to perinatal human immunodeficiency virus (HIV) infection and progression of HIV disease. The finding that Hardy-Weinberg equilibrium was obeyed for the cohort as a whole, as well as the discovery that the CCR532 heterozygotes were distributed statistically evenly between the uninfected and infected children, led them to conclude that such a genetic makeup did not confer resistance to HIV infection. It would be interesting to know the CCR5 genotype of the mothers of the children in the study population. Since it remains unclear exactly how heterozygosity for CCR532 changes the natural course of the disease, one can imagine that the CCR5 genotype of mother or child or both could play an important role in the risk of transmission.

Henry Rascoff
Albert Einstein College of Medicine
Bronx, NY

1. Misrahi M, Teglas J-P, N'Go N, et al. CCR5 chemokine receptor variant in HIV-1 mother-to-child transmission and disease progression in children. JAMA. 1998;279:277-280. FREE FULL TEXT

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