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Andrew A. Skolnick

JAMA. 1998;279:419.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

ALTHOUGH HIGHLY effective in blocking viral replication and improving the immune function of patients with human immunodeficiency virus (HIV) disease, protease inhibitor drugs are not able to cross the blood-brain barrier in therapeutic amounts. Therefore, these drugs were not expected to be effective in treating encephalopathy in patients with AIDS. However, a magnetic resonance imaging (MRI) study conducted at Yale University School of Medicine, New Haven, Conn, suggests that protease inhibitor therapy combined with drugs like zidovudine may prevent or even reverse the progression of HIV encephalopathy.

The results of the study (Radiology. In press), which were reported at the 83rd Scientific Assembly and Annual Meeting of the Radiological Society of North America in Chicago, Ill, show a strong relationship between the use of protease inhibitors and improvement in cognitive function and in the extent of brain involvement as seen on the MRI scans of patients . . . [Full Text of this Article]

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