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Rebecca Voelker

JAMA. 1998;279:420.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In a study that could further the understanding of antipsychotic drug action, researchers at the Institute of Psychiatry at the University of London in London, England, have identified an association between genetic variations in serotonin receptors and patient response to clozapine.

The researchers conducted genotype testing on 2 groups of patients. The first group consisted of 160 patients with diagnosed schizophrenia who did not respond to 2 other medications but had been treated with clozapine for 3 months. In the group, 58 were classified as nonresponders to clozapine. The second sample, chosen for replication studies of previous findings, consisted of 114 clozapine-treated patients, including 35 nonresponders.

Analysis of genotypes showed an association between polymorphisms in the promoter and coder regions of the serotonin receptor gene and patient response to clozapine. The researchers point out that clozapine is effective in up to 50% of patients who fail to respond . . . [Full Text of this Article]

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