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To the Editor.—In the article by Dr Pericak-Vance and colleagues,¹ data obtained from a genomic screen in families with late-onset Alzheimer disease (AD) suggest the existence of a potential genetic risk factor on chromosome 12. Parametric and nonparametric linkage analyses demonstrated the strongest association for D12S373, D12S1057,D12S1042, and D12S390 in families that had at least 1 affected individual whose apolipoprotein E (APOE) genotype did not contain the 4 allele (APOE 4), suggesting that this region may harbor a new late-onset AD susceptibility gene with little or no dependence on APOE 4.

In our studies in a large, multigenerational family with late-onset AD,² including a genomic screen, we have attempted to identify additional genetic factors contributing to familial AD. Preliminary 2-point linkage studies using an autosomal dominant and age-dependent penetrance model revealed a weak association in a 9-centimorgan (cM) region on chromosome 12 . . . [Full Text of this Article]

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RELATED ARTICLE

Complete Genomic Screen in Late-Onset Familial Alzheimer Disease: Evidence for a New Locus on Chromosome 12
Margaret A. Pericak-Vance, Meredyth P. Bass, Larry H. Yamaoka, Perry C. Gaskell, William K. Scott, Henry A. Terwedow, Marissa M. Menold, P. Michael Conneally, Gary W. Small, Jeffery M. Vance, Ann M. Saunders, Allen D. Roses, and Jonathan L. Haines
JAMA. 1997;278(15):1237-1241.
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