This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (10)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in JAMA  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor.— I disagree with the conclusions of the article by Dr Grönberg and colleagues¹ on the characteristics of prostate cancer in families potentially linked or potentially unlinked to the hereditary prostate cancer 1 (HPC1) gene.

First, on comparing the tumor stage in families potentially linked and those not shown to be linked, the authors state there is higher-stage disease with HPC1 linkage. This statement is based on a comparison with a reference population from the National Cancer Database but not with the unlinked families. When the linked and unlinked families are compared, there is no difference (P=.16, Fisher exact test).

Second, although there was a slightly greater proportion of grade 3 tumors in the HPC1- linked group, there were also more grade 1 tumors in linked families than in unlinked families. A trend toward higher-grade tumors with HPC1 positivity was not proven. If such . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Characteristics of Prostate Cancer in Families Potentially Linked to the Hereditary Prostate Cancer 1 (HPC1) Locus
Henrik Grönberg, Sarah D. Isaacs, Jeffrey R. Smith, John D. Carpten, G. Steven Bova, Diha Freije, Jianfeng Xu, Deborah A. Meyers, Francis S. Collins, Jeffrey M. Trent, Patrick C. Walsh, and William B. Isaacs
JAMA. 1997;278(15):1251-1255.
ABSTRACT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Clinical Characteristics of Prostate Cancer in an Analysis of Linkage to Four Putative Susceptibility Loci
Goode et al.
Clin. Cancer Res. 2001;7:2739-2749.
ABSTRACT | FULL TEXT  

Confirmation of Prostate Cancer Susceptibility Genes Using High-Risk Families
Jarvik et al.
J Natl Cancer Inst Monogr 1999;1999:81-87.
ABSTRACT | FULL TEXT