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To the Editor.— I disagree with the conclusions of the article by Dr Grönberg and colleagues¹ on the characteristics of prostate cancer in families potentially linked or potentially unlinked to the hereditary prostate cancer 1 (HPC1) gene.

First, on comparing the tumor stage in families potentially linked and those not shown to be linked, the authors state there is higher-stage disease with HPC1 linkage. This statement is based on a comparison with a reference population from the National Cancer Database but not with the unlinked families. When the linked and unlinked families are compared, there is no difference (P=.16, Fisher exact test).

Second, although there was a slightly greater proportion of grade 3 tumors in the HPC1- linked group, there were also more grade 1 tumors in linked families than in unlinked families. A trend toward higher-grade tumors with HPC1 positivity was not proven. If such . . . [Full Text of this Article]

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