This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (13)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Topic Collections  • Otolaryngology/ Head & Neck Surgery  • Hematology/ Hematologic Malignancies  • Leukemias/ Lymphomas  • Alert me on articles by topic  Social Bookmarking   What's this?

Lloyd B. Minor, MD

JAMA. 1998;279:541-544.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

CASE PRESENTATION

A 65-year-old man was referred to The Johns Hopkins Hospital Oncology Service for treatment of acute myelogenous leukemia. On admission, he had fevers, neutropenia, and erythematous papular lesions of the face and left antecubital fossa. Acinetobacter was cultured from his blood. Treatment included vancomycin, ciprofloxacin, and a 3-week course of gentamicin at a dose of 1.7 mg/kg intravenously every 8 hours. Predose and peak postdose gentamicin levels were checked on 4 occasions during treatment and never exceeded the therapeutic range, which is less than 2.5 mg/L within 30 minutes predose and less than 10 mg/L 1 hour postdose. On the fourth day of broad-spectrum antibiotic therapy, induction chemotherapy was begun with cytarabine, daunorubicin, and etoposide. During this period the patient developed Aspergillus pneumonia requiring treatment with amphotericin B.

The patient's condition improved, and a bone marrow aspirate about 30 days into the induction chemotherapy showed that . . . [Full Text of this Article]

DISCUSSION

Mechanisms of Gentamicin-Induced Vestibulotoxicity

Diagnosis of Vestibular Hypofunction

Bedside Tests of Vestibular Function

Quantitative Tests of Vestibular Function

Rehabilitation for Patients With Bilateral Vestibular Hypofunction

Minimizing the Risk of Vestibulotoxicity

From the Department of Otolaryngology–Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Disorders of Balance and Vestibular Function in US Adults: Data From the National Health and Nutrition Examination Survey, 2001-2004
Agrawal et al.
Arch Intern Med 2009;169:938-944.
ABSTRACT | FULL TEXT  

Aminoglycoside-Induced Vestibular Injury: Maintaining a Sense of Balance
Ariano et al.
The Annals of Pharmacotherapy 2008;42:1282-1289.
ABSTRACT | FULL TEXT  

Effects of Intratympanic Gentamicin on Vestibular Afferents and Hair Cells in the Chinchilla
Hirvonen et al.
J. Neurophysiol. 2005;93:643-655.
ABSTRACT | FULL TEXT