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Effects of Age and Ethnicity on the Link Between APOE 4 and Alzheimer Disease

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To the Editor.—The APOE and Alzheimer Disease Meta Analysis Consortium has produced a valuable data set.¹ Unfortunately, a comparison of Table 3 with Figure 4 suggests inconsistencies in their estimates. The odds ratio (OR) for apolipoprotein E (APOE) 3/4 for Japanese in Table 3 (5.6) is above the curve shown for Japanese in Figure 4. However, the clinic-based estimate for Caucasians (3.2) looks like the average of the points in Figure 4. Table 3 suggests the OR for APOE 3/4 is 75% higher among Japanese than among Caucasians. Figure 4 shows the difference is never more than 35% at any age. The differences between the methods used to derive these estimates might contribute to this.

First, Table 3 controls for differences among studies; Figure 4 does not. Failure to control for study can bias the results since there is substantial variation in both the number of . . . [Full Text of this Article]

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Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
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