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To the Editor.— Kaposi sarcoma (KS)–associated herpesvirus (KSHV, or human herpesvirus 8 [HHV-8]) has been causally linked to KS.^1-2 In the United Kingdom and the United States, sex between men may be an important route of transmission of HHV-8, because this is the main behavioral risk factor for KS in human immunodeficiency virus (HIV)–seropositive subjects. However, in parts of Africa where KS was seen in children even before the advent of the acquired immunodeficiency syndrome (AIDS),³ other routes of transmission also must occur.⁴

The Department of Human Genetics at the South African Institute of Medical Research in Johannesburg is responsible for testing mothers, children, and potential fathers in cases of disputed paternity. It is therefore possible to examine the relationship between seropositivity to HHV-8 in mothers and their children.

Stored serum samples from 107 healthy mothers (60 black, 24 white, 5 Asian, and 18 mixed race) with a median age . . . [Full Text of this Article]

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