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To the Editor.—Montelukast (MK-0476) is an orally administered, specific cysteinyl leukotriene receptor antagonist now with labeling approved by the Food and Drug Administration for the treatment of asthma. The study by Dr Knorr and colleagues¹ reported that montelukast improved morning forced expiratory volume in 1 second in 6- to 14-year-old children with chronic asthma. The most common adverse experiences were headache, asthma, and upper respiratory tract infection. However, the authors also reported an increase in fever (7.5% with montelukast vs 3.7% with placebo) and influenza (8.5% with montelukast vs 4.4% with placebo) and a decrease in abdominal pain (5% with montelukast vs 10.4% with placebo).

These observations raise 2 possibilities of potential clinical concern. First, the anti-inflammatory effect of montelukast might delay killing of virus by the immune system. Second, the anti-inflammatory effect of montelukast might mask the pain associated with abdominal infections.

The leukotriene receptors have not been . . . [Full Text of this Article]

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Montelukast for Chronic Asthma in 6- to 14-Year-Old Children: A Randomized, Double-blind Trial
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