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David H. P. Streeten, MB, DPhil, FRCP

JAMA. 1998;280:1094-1095.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Fatigue is a prominent accompaniment of a wide range of disorders, including acute or chronic infections, end-stage neoplasia, renal insufficiency, congestive heart failure, and some psychiatric illnesses. It has been speculated that the severe fatigue associated with neurocirculatory asthenia, termed irritable heart syndrome by Da Costa¹ and soldier's heart by Lewis² during World War I, were early descriptions of the symptoms of orthostatic hypotension.³ The common experience of severe fatigue after prolonged, exhausting physical labor or exercise and the muscular symptoms that sometimes accompany chronic fatigue syndrome (CFS) have stimulated research on the possible role of muscular disorders in its causation, but with unconvincing results. And, of course, a viral origin has been commonly considered to be a likely cause of chronic fatigue for many years.

In a careful study comparing patients who had all the features of CFS with age-matched controls, Demitrack . . . [Full Text of this Article]

From the State University of New York Health Science Center, Syracuse.

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