The Crisis in Clinical Research: Endangering the Half-Century National Institutes of Health Consensus

doi:10.1001/jama.280.16.1440

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Vol. 280 No. 16, October 28, 1998

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The Crisis in Clinical Research

Endangering the Half-Century National Institutes of Health Consensus

Alan N. Schechter, MD

JAMA. 1998;280:1440-1442.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Writing in THE JOURNAL in October 1952, Dr Norman H. Topping,associate director of the National Institutes of Health (NIH),announced the construction of the Clinical Center for medicalresearch in Bethesda, Md, with these words:

As far as research in our own laboratories is concerned, wehave concentrated almost exclusively on basic laboratory research.This work covers virtually every discipline related to medicine.. . . The great gap in this research program has been in clinicalresearch. We have been hampered for a number of years by inabilityto carry our laboratory findings through to clinical evaluation.We have also been hampered to an unknown but important degreeby the absence of the stimulus that clinical research offersto laboratory research. . . . The Clinical Center will providea means for bringing together in constant intellectual and physicalcontact outstanding practitioners in virtually . . . [Full Text of this Article]

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