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To the Editor.— The Medical News & Perspectives¹ article regarding the use of volunteers in a typhoid infection study was both fascinating and distressing.

The Food and Drug Administration committee members, the Center for Vaccine Development at the University of Maryland School of Medicine, the National Institute of Allergy and Infectious Diseases, and the World Health Organization have a laudable intent. However, in the tradition of their predecessors such as Hunter (syphilis), Walter Reed (yellow fever), Cournand (cardiac catheterization), and, more recently, Harrington et al² and Herbert,³ they should be willing to consider exposing themselves to the potential "minimal" risk of the study. Did the knowledgeable and informed members of these various institutions consider this option? If only 24 volunteers are needed, that likely is fewer than the potential number of authors of the article(s) describing the outcome.

Robert Matz, MD
Mount Sinai School of Medicine and Mount Sinai Hospital . . . [Full Text of this Article]

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