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Mike Mitka

JAMA. 1998;280:1648.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

COMEDIANS on late-night television got laughs when they noted that a bunch of old men in Sweden awarded the Nobel Prize in Medicine to three researchers whose work resulted in the creation of Viagra. But there's more to the story.

US pharmacologists Robert F. Furchgott, PhD, Ferid Murad, MD, PhD, and Louis J. Ignarro, PhD, didn't set out to make bedrooms exciting again for aging men, and that's not why they won the award. The Nobel assembly at the Karolinska Institute awarded the prize for their independent discoveries concerning "nitric oxide as a signaling molecule in the cardiovascular system."

Nitric oxide (NO) is most commonly known as an air pollutant formed when nitrogen burns, as it does in automobile engines. NO (not to be confused with the anesthetic gas nitrous oxide, N₂O) was known to be produced in bacteria, but its importance in mammals was not expected . . . [Full Text of this Article]

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