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The APOE- 4 Allele and Alzheimer Disease Among African Americans, Hispanics, and Whites
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To the Editor.—In the study by Dr Tang and colleagues,1 Hispanic subjects in a New York City community were at increased risk for developing Alzheimer disease (AD) compared with white non-Hispanic subjects. This elevated risk could not be attributed to the apolipoprotein E (APOE) genotype, since the relative risk of AD associated with the presence of an APOE- 4 allele was 2.5 for whites vs 1.1 for Hispanics.
In our memory disorders clinic, in Miami Beach, Fla, we assessed APOE genotypes among consecutive Hispanic patients with AD (n = 180) and healthy elderly controls (n = 64). All patients and controls provided informed consent. Our sample comprised primarily subjects born in Cuba who were self-reported or caregiver reported as Hispanic. The AD subjects (mean age, 76 ± 8 years; 69% female) were recruited and diagnosed at our memory disorders clinic as having probable or possible AD . . . [Full Text of this Article]
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