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Rebecca Voelker
JAMA contributor

JAMA. 1998;280:1735.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The immunosuppressive drug tacrolimus has been shown to be effective in combating atopic dermatitis in children when applied topically.

In a multicenter study, 180 children aged 7 to 16 years were randomized to receive one of three concentrations of tacrolimus or a placebo. All had moderate to severe atopic dermatitis affecting 5% to 30% of their skin surface. They were treated twice a day for up to 22 days, with a 2-week follow-up period. Researchers found that 69% of the children who received the lowest concentration (0.03%), 67% who received an intermediate concentration (0.1%), and 70% who received the highest concentration (0.3%) had marked improvement or clearing of their dermatitis. In comparison, only 38% in the placebo group showed similar improvement.

Some of the children treated with tacrolimus experienced a mild burning sensation of the skin that lasted about 4 days. However, the researchers noted that the drug . . . [Full Text of this Article]

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