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Judith L. Rapoport, MD

JAMA. 1998;280:1785-1786.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In this issue of THE JOURNAL, March et al¹ report the results of a multicenter, double-blind, placebo-controlled trial of sertraline hydrochloride for the treatment of obsessive-compulsive disorder (OCD) in children and adolescents. This article is gratifying in several ways. Obsessive-compulsive disorder has its onset in childhood or adolescence in approximately 50% of cases, and at least half of these cases benefit significantly from drug treatment.² The study by March et al¹ now extends to 3 the number of serotonin uptake–inhibiting drugs that have been demonstrated to be effective in children and adolescents in large multicenter trials. The others are clomipramine³ and fluvoxamine,⁴ and these 3 agents now have US Food and Drug Administration (FDA) approval for use in children and adolescents. In addition, 1 other selective serotonin reuptake inhibitor, fluoxetine, has been shown to be effective for childhood OCD in small controlled trials.⁵ Because OCD is . . . [Full Text of this Article]

From the Child Psychiatry Branch, National Institutes of Health, Bethesda, Md.

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Sertraline in Children and Adolescents With Obsessive-Compulsive Disorder: A Multicenter Randomized Controlled Trial
John S. March, Joseph Biederman, Robert Wolkow, Allan Safferman, Jack Mardekian, Edwin H. Cook, Neal R. Cutler, Roberto Dominguez, James Ferguson, Betty Muller, Robert Riesenberg, Murray Rosenthal, Floyd R. Sallee, and Karen D. Wagner
JAMA. 1998;280(20):1752-1756.
ABSTRACT | FULL TEXT  

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Sertraline Effectively Treats Children with OCD
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