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Joan Stephenson, PhD

JAMA. 1998;280:1978.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Scientists have determined the genetic sequence of chromosome 2 of Plasmodium falciparum, the deadliest of the four Plasmodium parasites that cause malaria in humans. The report, which appeared in the November 6 issue ofScience, is the first to describe the complete genetic sequence of a parasite chromosome.

Plasmodium falciparum (in yellow). (Photo credit: ©C. Meckes/Ottawa/Photo Researchers)

The work was a collaborative effort by investigators from the Institute for Genomic Research, Rockville, Md; the Naval Medical Research Center and the National Center for Biotechnology Information of the National Library of Medicine, both in Bethesda, Md; New York University, New York; and The Johns Hopkins University, Baltimore.

The effort resulted in the identification of more than 200 genes, many presumed to be essential to the parasite's pathogenicity, such as genes that may help P falciparum elude the immune response. Researchers say that the sequence information may . . . [Full Text of this Article]