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To the Editor.—In a recent meta-analysis of 17 prospective studies involving 47,000 subjects, elevated triglyceride levels were associated with an increase in coronary artery disease (CAD) risk of 30% in men and 75% in women.¹ In 1 study, the 8-year incidence of CAD was 14% in subjects with triglyceride levels of 1.60 to 2.50 mmol/L (142-221 mg/dL) vs 9.5% in those with cholesterol levels of about 8.00 mmol/L (310 mg/dL).² Miller et al³ found an odds ratio (OR) for CAD of 1.5 with a fasting triglyceride level of 1.13 mmol/L (100 mg/dL), whereas Stampfer et al⁴ found an OR of 1.4 per 1.13 mmol/L (100 mg/dL) increase in nonfasting triglycerides. An increase in triglycerides of 1.00 mmol/L (90 mg/dL) has the same effect on the extent of coronary atherosclerosis as would aging 10 years. Consequently, I was fascinated by the observations by Dr Lamarche and associates⁵ showing higher prevalence . . . [Full Text of this Article]

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